INT182278

Context Info Confidence 0.21 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 35 42.72 cytokine 3 5.00 rheumatoid arthritis 3 5.00 metalloproteinase 1 5.00 Inflammation 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 14 60.28 Osteoarthritis 36 50.00 Stress 3 10.88 Death 4 5.00 Rheumatoid Arthritis 3 5.00 Pain 1 5.00 Osteoporosis 1 5.00 Disease 1 5.00 Rheumatic Diseases 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

SB202190, a p38 inhibitor, completely suppressed the ET-1-stimulated production of both enzymes, whereas the phosphatidyl inositol 3 kinase inhibitor Wortmannin and the PKA inhibitor KT5720 partially but significantly (P < 0.01) decreased the level of MMP-13 only.

Negative_regulation (decreased) of Phosphorylation (level) of MMP-13

1) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.17 Pain Relevance 0

General Comments

This test has worked.