INT182282

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 82.88 Quite High
cytokine 4 26.56 Quite Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 36 82.88 Quite High
Stress 20 80.20 Quite High
Amyloid Plaque 35 69.88 Quite High
Alzheimer's Dementia 36 5.00 Very Low Very Low Very Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistently, pretreatment with JNK inhibitor SP600125 also decreased JNK activation (Fig. 5B, lane 4).
Negative_regulation (decreased) of JNK Binding (pretreatment) of
1) Confidence 0.39 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.21 Pain Relevance 0
This effect occurs within minutes following a challenge with ET-1, and disappears after 45 and 60 min for the p-38 and SAP/JNK kinases, respectively.
Negative_regulation (kinases) of JNK Binding (min) of
2) Confidence 0.17 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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