INT182285

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.37
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL5A2) molecular_function (COL5A2)
Anatomy Link Frequency
cartilage 2
COL5A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 99.84 Very High Very High Very High
dexamethasone 195 96.36 Very High Very High Very High
cytokine 3 82.00 Quite High
rheumatoid arthritis 3 57.92 Quite High
corticosteroid 3 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 36 99.84 Very High Very High Very High
Rheumatic Diseases 1 70.96 Quite High
Rheumatoid Arthritis 3 57.92 Quite High
Rupture 18 5.00 Very Low Very Low Very Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Tendinopathy 12 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However the rate of increase between the first and second week of culture was far greater for collagen accumulation than for cell number with a 100% increase in the amount of collagen compared with about 25% increase in cell number in the control cultures suggesting a process of differentiation and specific increase in collagen accumulation (Fig. 3A).
Positive_regulation (increase) of Positive_regulation (accumulation) of collagen
1) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.29
However, after 2 weeks in culture the pattern changed in that the control cultures showed a proportionally greater increase in collagen accumulation than the PT cultures.
Positive_regulation (increase) of Positive_regulation (accumulation) of collagen
2) Confidence 0.13 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.26
However the rate of increase between the first and second week of culture was far greater for collagen accumulation than for cell number with a 100% increase in the amount of collagen compared with about 25% increase in cell number in the control cultures suggesting a process of differentiation and specific increase in collagen accumulation (Fig. 3A).
Positive_regulation (increase) of Positive_regulation (accumulation) of collagen
3) Confidence 0.09 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2515295 Disease Relevance 0 Pain Relevance 0.34
Interestingly, using a specific immunoassay measuring the C telopeptide of type II collagen fragments on OA cartilage explants, we also found that the level of the cleaved collagen fragments were significantly increased in the presence of both IL-1?
Positive_regulation (measuring) of Positive_regulation (fragments) of collagen in cartilage associated with osteoarthritis
4) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.37 Pain Relevance 0.19

General Comments

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