INT182293

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.60
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK8) nucleoplasm (MAPK8) mitochondrion (MAPK8)
nucleus (MAPK8) response to stress (MAPK8) cytoplasm (MAPK8)
MAPK8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 249 98.48 Very High Very High Very High
agonist 46 97.24 Very High Very High Very High
Inflammatory response 11 96.24 Very High Very High Very High
ischemia 2 89.04 High High
cytokine 29 84.72 Quite High
Osteoarthritis 35 82.88 Quite High
Inflammatory mediators 5 65.36 Quite High
Rheumatism 2 57.00 Quite High
Arthritis 12 56.56 Quite High
cerebral cortex 1 55.12 Quite High
Disease Link Frequency Relevance Heat
Colitis 18 99.08 Very High Very High Very High
INFLAMMATION 272 98.84 Very High Very High Very High
Colon Cancer 28 92.72 High High
Stress 46 92.12 High High
Amyloid Plaque 70 89.92 High High
Microcephaly 8 89.48 High High
Cv Unclassified Under Development 2 89.04 High High
Congenital Anomalies 22 88.72 High High
Reperfusion Injury 2 88.32 High High
Cancer 209 86.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that JNK phosphorylates APP and thereby makes it a better substrate for ?
JNK Binding (makes) of
1) Confidence 0.34 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.18 Pain Relevance 0.04
Consistently, pretreatment with JNK inhibitor SP600125 also decreased JNK activation (Fig. 5B, lane 4).
JNK Binding (pretreatment) of
2) Confidence 0.34 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.21 Pain Relevance 0
As shown in Figure 3B, the cytotoxicity of Pa-PDT was inhibited in the R-HepG2 cells when the cells were pre-treated with JNK inhibitor, where the cell viabilities could be restored to 80.5% and 48.5% in the 0.75 ?
JNK Binding (inhibitor) of
3) Confidence 0.23 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.44 Pain Relevance 0
A recent study demonstrates that JNK directly binds to and phosphorylates ?
JNK Binding (binds) of
4) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.43 Pain Relevance 0
This effect occurs within minutes following a challenge with ET-1, and disappears after 45 and 60 min for the p-38 and SAP/JNK kinases, respectively.
JNK Binding (min) of
5) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.08 Pain Relevance 0.04
Our results from the microarray analysis indicated the JNK and NF-?
JNK Binding (indicated) of
6) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.22 Pain Relevance 0.05
Seven genes reside in the duplicated area, which contains SHANK3, ACR, RABL2B, MAPK8IP2 (mitogen-activated protein kinase 8 interacting) and ARSA (arylsulfatase A, isoform b).
mitogen-activated protein kinase 8 Binding (interacting) of
7) Confidence 0.13 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.84 Pain Relevance 0.03
Minutoli et al., demonstrated the abrogation of JNK and p38 signals, but enhancement of ERK 1/2 activity by disruption of the transcriptional factor NF-?
JNK Binding (abrogation) of
8) Confidence 0.10 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.25 Pain Relevance 0.04
In more precise investigation with specific JNK inhibitor SP600215, we further showed that the combination treatment of JNK inhibitor with bee venom and melittin suppressed inhibitory effects of melittin and bee venom on the LPS and SNP-induced NO and PGE2 release with the suppressed effect on the inhibitory effect of melittin and bee venom on the NF-?
JNK Binding (investigation) of
9) Confidence 0.10 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.33 Pain Relevance 0.17
activity of the MAPKs p38 and the c-Jun N-terminal kinase (JNK), and of NF-?
c-Jun N-terminal kinase Binding (activity) of
10) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.81 Pain Relevance 0.20
activity of the MAPKs p38 and the c-Jun N-terminal kinase (JNK), and of NF-?
JNK Binding (activity) of
11) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.81 Pain Relevance 0.20

General Comments

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