INT182295

Context Info Confidence 0.27 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 3.33 Pain Relevance 1.77

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 299 100.00 metalloproteinase 52 100.00 Inflammation 45 100.00 cytokine 34 70.96 agonist 8 22.16 cINOD 8 5.00 Inflammatory mediators 6 5.00 COX2 6 5.00 Hyperalgesia 6 5.00 rheumatoid arthritis 5 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 304 100.00 INFLAMMATION 48 100.00 Obesity 104 99.48 Osteoporosis 13 91.72 Hypercalcemia 22 59.36 Overweight 13 57.36 Disease 25 5.00 Apoptosis 24 5.00 Cancer 10 5.00 Hyperalgesia 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The most striking effects of leptin in obese patients, that is the up-regulation of IGF-1, collagen type 2 and MMP-13, were found with the highest concentration of leptin.

Regulation (regulation) of MMP-13 associated with obesity

1) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.99 Pain Relevance 0.06

had no effect on the level of MMP-13 produced by Raw 264.7 cells (n = 8).

Regulation (effect) of MMP-13

2) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.26 Pain Relevance 0.09

To determine the functional consequence of PAR-2 activation, we studied some of the major catabolic/inflammatory factors involved in OA pathophysiology, including MMP-1, MMP-13, and COX-2 (Figure 4).

Regulation (some) of MMP-13 associated with inflammation, metalloproteinase and osteoarthritis

3) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.77 Pain Relevance 0.66

To determine the functional consequence of PAR-2 activation, we studied some of the major catabolic/inflammatory factors involved in OA pathophysiology, including MMP-1, MMP-13, and COX-2 (Figure 4).

Regulation (involved) of MMP-13 associated with inflammation, metalloproteinase and osteoarthritis

4) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 0.71 Pain Relevance 0.63

This suggests that these inhibitors are specific for the ET-1-activated pathways since they do not affect the basal levels of MMP-1 and MMP-13.

Neg (not) Regulation (affect) of MMP-13

5) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.22 Pain Relevance 0.15

These findings also agree with studies on other cell types demonstrating the critical role of ERK1/2 and p38 activation in the regulation of MMP-13 as well as with data showing that rhein reduces the IL-1?

Regulation (regulation) of MMP-13

6) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.38 Pain Relevance 0.20

General Comments

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