INT182302

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.52
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 35 70.56 Quite High
antagonist 2 55.56 Quite High
headache 2 33.36 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 66 99.86 Very High Very High Very High
Adenocarcinoma 6 96.00 Very High Very High Very High
Endometrial Hyperplasia 4 95.28 Very High Very High Very High
Apoptosis 74 93.00 High High
Cancer 190 89.80 High High
Cervical Cancer 5 86.48 High High
Endometrial Cancer 153 84.24 Quite High
Necrosis 1 82.36 Quite High
Death 31 81.04 Quite High
Hyperglycemia 2 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Fig. 2A, a decline in the abundance of Akt protein was apparent following 16 hours of valproic acid or butyrate treatment, which became more evident after 24 hours of treatment.
Negative_regulation (decline) of Localization (abundance) of Akt
1) Confidence 0.39 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.09 Pain Relevance 0
As described above, PTEN antagonizes the PI3K/AKT pathway by dephosphorylating PIP3, resulting in decreased translocation of AKT activation.
Negative_regulation (decreased) of Localization (translocation) of AKT
2) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.80 Pain Relevance 0
In the setting of hormone receptor positive breast cancer, mTOR inhibition and the resulting increase in Akt signaling could result in ER phosphorylation on Ser167 and negate the effects of aromatase inhibition, thus limiting the therapeutic benefit of this combination.


Negative_regulation (inhibition) of Localization (increase) of Akt associated with breast cancer
3) Confidence 0.22 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.65 Pain Relevance 0
At this time (45 min), both p38 kinase and Akt phosphorylated forms were diminished.
Negative_regulation (diminished) of Localization (forms) of Akt
4) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.39 Pain Relevance 0.04
HSP90 inhibitors affect AKT activity indirectly through depletion of upstream signaling molecules (for example, ERBB family members) and directly by preventing HSP90-dependent conformational stability of AKT [17,21,22].
Negative_regulation (preventing) of Localization (stability) of AKT
5) Confidence 0.16 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.60 Pain Relevance 0.03

General Comments

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