INT182311

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 25.32
Pain Relevance 4.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
joint 3
lymph node 2
plasma 2
synovial fluid 1
PC-3 1
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 808 99.56 Very High Very High Very High
hyperexcitability 3 99.28 Very High Very High Very High
Arthritis 48 98.52 Very High Very High Very High
Inflammation 165 96.92 Very High Very High Very High
Hippocampus 39 95.16 Very High Very High Very High
interneuron 3 94.24 High High
cINOD 51 93.84 High High
GABAergic 21 88.88 High High
methotrexate 204 87.76 High High
Neuropeptide 6 86.16 High High
Disease Link Frequency Relevance Heat
Convulsion 117 100.00 Very High Very High Very High
Breast Cancer 195 99.92 Very High Very High Very High
Apoptosis 663 99.86 Very High Very High Very High
Arthropathy 384 99.60 Very High Very High Very High
Rheumatoid Arthritis 808 99.56 Very High Very High Very High
Nasopharynx Cancer 145 99.52 Very High Very High Very High
Disease 257 99.12 Very High Very High Very High
Death 116 98.76 Very High Very High Very High
Arthritis 48 98.52 Very High Very High Very High
Non-small-cell Lung Cancer 3 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, patients with elevated levels of survivin have significantly worse disease-free survival and overall survival than do patients with lower levels of survivin.
Positive_regulation (elevated) of survivin associated with disease
1) Confidence 0.67 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.98 Pain Relevance 0
Furthermore, studies with the use of non-small cell lung cancer (NSCLC) cell lines have indicated that increased COX-2 activity might contribute to the stabilization of survivin in these cells [59,60].
Positive_regulation (stabilization) of survivin in lung associated with lung cancer and non-small-cell lung cancer
2) Confidence 0.67 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.33 Pain Relevance 0.17
Increased survivin levels are significantly associated with high nuclear grade, negative hormone receptor status, HER2 over-expression, VEGF expression, and high urokinase-type plasminogen activator and plasminogen activator inhibitor-1 levels.
Positive_regulation (Increased) of survivin
3) Confidence 0.67 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.06 Pain Relevance 0
However, the improvements were minimal as compared with controls, and the escape latency and path length were significantly increased in the SurvivinCamcre mice (p < 0.001, n = 12; by two way repeated measures ANOVA) (Figure 8A, B).
Positive_regulation (increased) of SurvivinCamcre
4) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.12 Pain Relevance 0.04
To study the in vivo role of NPC survivin, we generated mice in which the survivin gene is inactivated in the neurogenic regions of the brain prenatally.
Positive_regulation (inactivated) of survivin gene in neurogenic regions
5) Confidence 0.50 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.07 Pain Relevance 0.05
For example, the pair of prostate carcinoma cell lines, MIA-PaCa-2 and Bx-PC-3, displayed a noticeable difference in their basal levels of survivin and in their response to the drugs, even though these cells both harbor mutant p53.
Positive_regulation (response) of survivin in PC-3 associated with prostate cancer
6) Confidence 0.49 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.68 Pain Relevance 0
Stat3-mediated induction of survivin not only suppresses apoptosis, but also promotes mitogenic progression through binding to cdc2 [63,64].
Positive_regulation (induction) of survivin associated with apoptosis
7) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.37 Pain Relevance 0.05
We also observed the increased expression of anti-apoptotic genes like Birc5 (Survivin) and Hells (Figure 6).
Spec (like) Positive_regulation (like) of Survivin associated with apoptosis
8) Confidence 0.49 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.90 Pain Relevance 0
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Positive_regulation (increased) of survivin
9) Confidence 0.45 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.07 Pain Relevance 0
NPC samples expressed high levels of survivin and livin, which might play an important role in the oncogenesis and tumour development.
Positive_regulation (levels) of survivin associated with cancer and nasopharynx cancer
10) Confidence 0.45 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.49 Pain Relevance 0
Due to the increased seizure activity in the SurvivinCamcre mice, we examined NPY expression under both basal conditions (saline treatment) and following induction of seizures (KA 20 mg/kg i.p.).
Positive_regulation (increased) of SurvivinCamcre associated with convulsion
11) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.77 Pain Relevance 0.18
We also observed the increased expression of anti-apoptotic genes like Birc5 (Survivin) and Hells (Figure 6).
Spec (like) Positive_regulation (like) of Birc5 associated with apoptosis
12) Confidence 0.38 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.90 Pain Relevance 0
Moreover, the ratio of survivin-2B/survivin was increased in patients with higher stages and with pelvic lymph node metastasis.
Positive_regulation (increased) of survivin in lymph node associated with metastasis
13) Confidence 0.34 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 0.97 Pain Relevance 0.07
Moreover, the ratio of survivin-2B/survivin was increased in patients with higher stages and with pelvic lymph node metastasis.
Positive_regulation (increased) of survivin in lymph node associated with metastasis
14) Confidence 0.23 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 1.02 Pain Relevance 0.07
In addition, we reported that survivin-2B-specific CTLs could be induced efficiently from PBMCs of HLA-A24-positive survivin-positive cancer patients [17].
Positive_regulation (induced) of survivin in A24 associated with cancer
15) Confidence 0.21 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 0.95 Pain Relevance 0
Taking into account the fact that the increased survivin levels were observed predominantly among the ERA patients, we assessed the effect of DMARD treatment on survivin levels in this patient group.
Positive_regulation (increased) of survivin associated with arthropathy
16) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.81 Pain Relevance 0.33
We also showed that the decrease of survivin levels could be mediated by treatment with DMARDs.
Positive_regulation (mediated) of survivin
17) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.72 Pain Relevance 0.46
Indeed, using logistic regression analysis, we demonstrated that RA patients having high levels of survivin had a 16 times higher risk to develop destructive joint disease as compared with the patients with low levels of survivin.
Positive_regulation (levels) of survivin in joint associated with rheumatoid arthritis and arthropathy
18) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 1.42 Pain Relevance 0.29
We observed that survivin levels were clearly increased in synovial fluid and plasma of RA patients compared with the healthy controls.
Positive_regulation (increased) of survivin in plasma associated with rheumatoid arthritis
19) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 1.32 Pain Relevance 0.29
In all the cases but one, high levels of survivin were associated with the erosive type of joint disease.
Positive_regulation (levels) of survivin in joint associated with arthropathy
20) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.77 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox