INT182312

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 25.30
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
pleura 3
MCF-7 2
THP-1 2
nucleus 2
thymus 2
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 21 99.76 Very High Very High Very High
Chronic pancreatitis 6 99.50 Very High Very High Very High
cytokine 35 99.46 Very High Very High Very High
Inflammation 60 99.26 Very High Very High Very High
Taxol 2 99.18 Very High Very High Very High
rheumatoid arthritis 337 98.72 Very High Very High Very High
fibrosis 30 94.88 High High
GABAergic 21 94.48 High High
Inflammatory stimuli 5 94.00 High High
cINOD 31 90.84 High High
Disease Link Frequency Relevance Heat
Apoptosis 551 100.00 Very High Very High Very High
Neurodegenerative Disease 83 99.96 Very High Very High Very High
Cancer 796 99.84 Very High Very High Very High
Diabetes Mellitus 186 99.68 Very High Very High Very High
Carcinoma In Situ 5 99.62 Very High Very High Very High
Lung Cancer 287 99.52 Very High Very High Very High
Pancreatic Cancer 272 99.52 Very High Very High Very High
Pancreatitis 6 99.50 Very High Very High Very High
Malignant Neoplastic Disease 53 99.48 Very High Very High Very High
INFLAMMATION 83 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, these preliminary findings suggest that enhanced expression of NPC survivin may increase neurogenesis.


Positive_regulation (enhanced) of Gene_expression (expression) of survivin associated with neurodegenerative disease
1) Confidence 0.69 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.36 Pain Relevance 0.11
In previous reports, survivin overexpression was correlated with poor prognosis in some gastrointestinal malignancies such as gastric cancer and pancreatic cancer [8].
Positive_regulation (overexpression) of Gene_expression (overexpression) of survivin associated with pancreatic cancer and stomach cancer
2) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.27 Pain Relevance 0.03
LN also caused an increase in the expression of survivin and the phosphorylation of Bad at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 in AsPC-1cells (Fig. 10D).
Positive_regulation (increase) of Gene_expression (expression) of survivin
3) Confidence 0.67 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.38 Pain Relevance 0
Exposure of MCF-7 cells to adriamycin, taxol, or UVB results in fourfold to fivefold increased expression of survivin.
Positive_regulation (increased) of Gene_expression (expression) of survivin in MCF-7 associated with taxol
4) Confidence 0.67 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.39 Pain Relevance 0.09
Our treatment strategy leading to the coexpression of VEGF and Ang-1 might have led to the increased expression of survivin through the activation of NF?
Positive_regulation (increased) of Gene_expression (expression) of survivin
5) Confidence 0.67 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.82 Pain Relevance 0.10
Overexpression of survivin was related with poor prognosis, suggesting that the determination of survivin expression might provide predictive information on NPC patients [56].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of survivin associated with nasopharynx cancer
6) Confidence 0.67 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.48 Pain Relevance 0
Overall, these preliminary findings suggest that enhanced expression of NPC survivin may increase neurogenesis.


Spec (may) Positive_regulation (increase) of Gene_expression (expression) of survivin associated with neurodegenerative disease
7) Confidence 0.50 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.36 Pain Relevance 0.11
When two different tumor cell lines were treated with various concentrations of the above inhibitors, no effect on survivin expression was observed, even at concentrations of up to 100 ?
Neg (no) Positive_regulation (on) of Gene_expression (expression) of survivin associated with cancer
8) Confidence 0.49 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.15 Pain Relevance 0.16
Similarly, we observed a significant increase in the expression of survivin in the diabetic animals that received the therapy (DVAMI, 7.2-fold) 4 days after the treatment compared with the Ad.LacZ-treated diabetic MI (DLZMI) group (Fig. 4C and D).


Positive_regulation (increase) of Gene_expression (expression) of survivin associated with diabetes mellitus and myocardial infarction
9) Confidence 0.49 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.17 Pain Relevance 0
While these reports indicate a role of COX-2 in the expression of survivin, it appears that this observation cannot be generalized, as we have not observed a correlation between COX-2 activity and the expression levels of survivin in the various tumor cells lines used in our study (Figure 2).
Positive_regulation (role) of Gene_expression (expression) of survivin associated with cancer
10) Confidence 0.49 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.40 Pain Relevance 0.16
The hypoplastic OB and absent RMS, in concert with reduced expression of NPC survivin in the SurvivinCamcre mice might be caused by decreased NPC proliferation, increased cell death, and/or deficits in migration.
Positive_regulation (caused) of Gene_expression (expression) of survivin associated with death
11) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.10 Pain Relevance 0.04
We also observed the increased expression of anti-apoptotic genes like Birc5 (Survivin) and Hells (Figure 6).
Positive_regulation (increased) of Gene_expression (expression) of Survivin associated with apoptosis
12) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.92 Pain Relevance 0
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Positive_regulation (increased) of Gene_expression (levels) of survivin
13) Confidence 0.45 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.07 Pain Relevance 0
In that report, we demonstrated that overexpression of survivin was detected in surgically resected primary tumor specimens of most breast cancers in an immunohistochemical study.
Positive_regulation (overexpression) of Gene_expression (overexpression) of survivin associated with cancer and breast cancer
14) Confidence 0.34 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 1.26 Pain Relevance 0
We previously demonstrated that the expression of survivin-2B was detected in a variety of tumor cell lines but not in normal tissues except in the thymus, although low levels of survivin expression were detected by reverse transcription-PCR analysis [16].
Positive_regulation (detected) of Gene_expression (expression) of survivin in thymus associated with cancer
15) Confidence 0.23 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 0.99 Pain Relevance 0
B is then translocated into the nucleus where it binds to specific sequences of DNA and activates the expression of some anti-apoptosis genes, such as Bcl-2, Survivin, XIAP, and IAPs [15,16].
Positive_regulation (activates) of Gene_expression (expression) of Survivin in nucleus associated with apoptosis
16) Confidence 0.16 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.94 Pain Relevance 0.06
We did not explain this discrepancy, but we suggested that venous invasion may be an independent prognostic factor irrelevant to survivin expression.
Positive_regulation (irrelevant) of Gene_expression (expression) of survivin
17) Confidence 0.07 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 1.20 Pain Relevance 0
Of the 49 cases of pancreatic cancer, 46 cases (93.9%) were positive for survivin expression.
Positive_regulation (positive) of Gene_expression (expression) of survivin associated with pancreatic cancer
18) Confidence 0.07 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1266027 Disease Relevance 0.49 Pain Relevance 0
Although the findings were statistically not significant, there was a suggestion that non-responder group showed high survivin expression.
Positive_regulation (high) of Gene_expression (expression) of survivin
19) Confidence 0.07 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.79 Pain Relevance 0
Previous study found survivin and p53 may play important roles in the transition from adenoma to carcinoma in situ in IPMT, and that survivin expression was higher in p53-positive pancreatic cancers [18,19].
Positive_regulation (higher) of Gene_expression (expression) of survivin associated with adenoma, cancer, pancreatic cancer and carcinoma in situ
20) Confidence 0.07 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1266027 Disease Relevance 0.98 Pain Relevance 0

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