INT182314

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.69
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
cortex 1
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 13 98.64 Very High Very High Very High
rheumatoid arthritis 134 92.12 High High
headache 4 70.40 Quite High
Inflammation 21 62.00 Quite High
Inflammatory response 6 45.04 Quite Low
cytokine 8 42.52 Quite Low
Thalamus 1 8.32 Low Low
amygdala 1 6.16 Low Low
methotrexate 34 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 46 99.48 Very High Very High Very High
Skin Cancer 11 93.92 High High
Rheumatoid Arthritis 134 92.12 High High
Apoptosis 64 87.08 High High
Malignant Neoplastic Disease 2 79.84 Quite High
Ovarian Cancer 2 79.12 Quite High
Fever 5 78.72 Quite High
Fatigue 9 78.16 Quite High
Vomiting 6 77.44 Quite High
Death 18 77.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both the embryo or adult, survivin is not detected in neurons in the cortex, OB, or hippocampus.


Neg (not) Transcription (detected) of survivin in cortex associated with hippocampus
1) Confidence 0.69 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.06 Pain Relevance 0.05
Survivin gene transcription is repressed by wild-type p53 [24-26].
Transcription (transcription) of Survivin
2) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 1.28 Pain Relevance 0.25
Interaction with survivin transcription
Transcription (transcription) of survivin
3) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0 Pain Relevance 0
LY2181308 is a new 2'-O-methoxymethyl modified antisense oligonucleotide (ASO) designed to inhibit survivin mRNA expression [20].
Transcription (expression) of survivin
4) Confidence 0.02 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.36 Pain Relevance 0.07

General Comments

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