INT182315

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.79
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 67 92.32 High High
Arthritis 4 88.56 High High
cytokine 4 77.16 Quite High
Inflammation 11 75.60 Quite High
chemokine 1 64.04 Quite High
Inflammatory stimuli 1 58.52 Quite High
aspirin 13 50.00 Quite Low
methotrexate 17 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 4 95.92 Very High Very High Very High
Apoptosis 37 93.04 High High
Rheumatoid Arthritis 67 92.32 High High
Cancer 71 90.40 High High
Arthritis 4 88.56 High High
Ovarian Cancer 33 82.72 Quite High
INFLAMMATION 16 75.60 Quite High
Skin Cancer 1 75.24 Quite High
Lung Cancer 1 64.76 Quite High
Arthropathy 32 48.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Positive_regulation (increased) of Negative_regulation (decreased) of survivin
1) Confidence 0.45 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.07 Pain Relevance 0
We also showed that the decrease of survivin levels could be mediated by treatment with DMARDs.
Positive_regulation (mediated) of Negative_regulation (decrease) of survivin
2) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.72 Pain Relevance 0.46

General Comments

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