INT182318

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 23.58
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
joint 1
MIA PaCa-2 1
T98G 1
MG-63 1
AsPC-1 1
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 347 100.00 Very High Very High Very High
Inflammatory response 20 98.22 Very High Very High Very High
cINOD 154 95.92 Very High Very High Very High
methotrexate 85 87.92 High High
cytokine 49 85.32 High High
Inflammation 95 84.92 Quite High
COX-2 inhibitor 88 84.88 Quite High
member 8 3 65.40 Quite High
headache 5 52.48 Quite High
Thoracotomy 6 48.64 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 1004 100.00 Very High Very High Very High
Rheumatoid Arthritis 347 100.00 Very High Very High Very High
Arthropathy 160 99.92 Very High Very High Very High
Death 193 99.68 Very High Very High Very High
Osteogenic Sarcomas 2 99.44 Very High Very High Very High
Pancreatic Cancer 119 99.16 Very High Very High Very High
Cancer 1507 99.12 Very High Very High Very High
Repression 49 98.96 Very High Very High Very High
Metastasis 60 98.64 Very High Very High Very High
INFLAMMATION 134 98.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicated that in AsPC-1 cells, LN-induced FAK phosphorylation mediated the intrinsic chemoresistance to Gem, and this effect might be related with the regulation of survivin and pBad (pS136) level

Effects of PF-228 on Gem-induced apoptosis in pancreatic cancer cells

Regulation (regulation) of survivin in AsPC-1 associated with pancreatic cancer and apoptosis
1) Confidence 0.60 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.47 Pain Relevance 0
To determine whether survivin expression was similarly affected by these drugs, we generated cells that were stably transfected with luciferase reporter constructs under the control of the survivin promoter.
Regulation (control) of survivin
2) Confidence 0.60 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.30 Pain Relevance 0.15
Troglitazone lead to a marked down-regulation of the antiapoptotic proteins FLIP and Survivin.
Regulation (regulation) of Survivin
3) Confidence 0.44 Published 2010 Journal PPAR Research Section Body Doc Link PMC2841252 Disease Relevance 2.03 Pain Relevance 0.03
Celecoxib triggered also apoptosis in osteosarcoma cells (MG-63) through down-regulation of Bcl-2, survivin and PI3K (phosphoinositide 3-kinase) pathway [112].
Regulation (regulation) of survivin in MG-63 associated with osteogenic sarcomas and apoptosis
4) Confidence 0.44 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.22 Pain Relevance 0.10
From these earlier results, one might expect that the down-regulation of survivin by celecoxib or DMC should sensitize these cells to other cancer drugs.
Regulation (regulation) of survivin associated with cancer
5) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.71 Pain Relevance 0
Our efforts to understand the mechanisms by which DMC accomplishes the down-regulation of survivin revealed that at least part of this regulation occurs at the level of transcription, i.e., our results clearly indicate that DMC is able to potently inhibit survivin expression at the gene level via the inhibition of promoter activity (Figure 4).
Regulation (regulation) of survivin
6) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.45 Pain Relevance 0
Down-regulation of survivin is independent of p53
Regulation (regulation) of survivin
7) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.83 Pain Relevance 0
Because the above results indicated a certain cell type-specific sensitivity with regards to the down-regulation of survivin, we comparatively analyzed several relevant parameters in these cell lines.
Regulation (regulation) of survivin
8) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.84 Pain Relevance 0
Down-regulation of survivin is independent of cyclooxygenase-2
Regulation (regulation) of survivin
9) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.47 Pain Relevance 0
On the other hand, at these same concentrations of DMC, LN229 and MIA PaCa-2 cells exhibited only a minor down-regulation of survivin, which correlated with marginally increased apoptosis and a much weaker effect on overall cell survival (Figure 5).
Regulation (regulation) of survivin in MIA PaCa-2 associated with apoptosis
10) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.82 Pain Relevance 0
Down-regulation of survivin involves transcriptional repression
Regulation (regulation) of survivin associated with repression
11) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.35 Pain Relevance 0.24
In the present report, we demonstrate that survivin, a protein that is critically involved in the regulation of mitosis and the protection of cells from apoptosis, is potently down-regulated by celecoxib and by DMC in all tumor cell lines examined.
Spec (examined) Regulation (regulated) of survivin associated with cancer and apoptosis
12) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.89 Pain Relevance 0.05
As shown in Figure 5, U251, T98G, and BxPc-3 cells responded quite sensitively; these cells displayed a potent down-regulation of survivin, and at the same time strongly increased apoptosis in combination with greatly reduced survival.
Regulation (regulation) of survivin in T98G associated with apoptosis
13) Confidence 0.44 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.73 Pain Relevance 0
Although the above described transcriptional events are quite prominent, additional levels of survivin regulation by celecoxib and DMC are likely.
Regulation (regulation) of survivin
14) Confidence 0.26 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.28 Pain Relevance 0
In addition, survivin exression was also regulated by FAK phosphorylation.
Regulation (regulated) of survivin
15) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.93 Pain Relevance 0
Further investigations showed that Akt 2 activation protects against docetaxel-induced apoptosis by regulating survivin levels in a PI3K-dependent manner.
Regulation (regulating) of survivin associated with apoptosis
16) Confidence 0.26 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.91 Pain Relevance 0
In summary, we identified important genes that are altered at the transcriptional level by E6 in our model, in particular the uncoupling of cell cycle regulation (cdc2, cyclin B, cdk2 and cyclin E), down-regulation of pro-apoptotic genes (Fas) and up-regulation of anti-apoptotic genes (Birc5).
Regulation (regulation) of Birc5 associated with apoptosis
17) Confidence 0.21 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.49 Pain Relevance 0
Finally, at 7 days, the top networks are focused on immunomodulation and inflammatory responses (up-regulation of NPPA/ANP and Brca1 - Figure 5A), and continued cell proliferation (up-regulation of Birc5, Foxm1, Cdc2, Ccnb1 and Ccna2 - Figure 5B).


Regulation (regulation) of Birc5 associated with inflammatory response
18) Confidence 0.17 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.42 Pain Relevance 0.21
These reports might support the idea that survivin-2B is the ideal target of immunotherapy for cancer patients [17,39], especially for those with advanced or recurrent cancer.
Regulation (target) of survivin associated with cancer
19) Confidence 0.13 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 1.17 Pain Relevance 0.07
Thus, survivin is a suitable target for immune therapy for cancer [26,29].
Regulation (target) of survivin associated with cancer
20) Confidence 0.13 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 1.36 Pain Relevance 0

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