INT182319

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.13
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
joints 1
leukocyte 1
brains 1
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 134 98.96 Very High Very High Very High
member 8 3 56.92 Quite High
Hippocampus 26 48.56 Quite Low
Inflammation 20 46.48 Quite Low
amygdala 2 34.12 Quite Low
Thalamus 2 33.04 Quite Low
long-term potentiation 6 22.16 Low Low
Inflammatory stimuli 2 10.64 Low Low
methotrexate 34 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 6 99.08 Very High Very High Very High
Rheumatoid Arthritis 134 98.96 Very High Very High Very High
Cancer 164 97.88 Very High Very High Very High
Targeted Disruption 2 90.80 High High
Metastasis 39 89.76 High High
Arthropathy 64 89.52 High High
Stress 12 88.56 High High
Malignant Neoplastic Disease 8 87.68 High High
Brain Tumor 3 86.88 High High
Glioma 3 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Schütz, Heidelberg, Germany) were bred with mice in which the survivin gene is flanked by loxP sites [32].
Localization (flanked) of survivin gene
1) Confidence 0.75 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.47 Pain Relevance 0
Adult SurvivinCamcre mice also had significantly smaller brains, and the OBs were strikingly hypoplastic (Figure 4A, B) (for brains: 421 ± 11 gm versus 329 ± 7 gm, for controls versus SurvivinCamcre, respectively, p < 0.001; for OBs: 19.7 ± 0.9 gm versus 3.5 ± 0.2 gm for controls versus SurvivinCamcre, p < 0.001; n = 6 mice per group).
Localization (respectively) of SurvivinCamcre in brains
2) Confidence 0.65 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.24 Pain Relevance 0
As described above, we are sure that survivin-targeting immunotherapy with survivin-2B peptide should be a reasonable strategy.
Localization (targeting) of survivin
3) Confidence 0.36 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 0.77 Pain Relevance 0
On the other hand, Mahotka et al. [40] reported that the ratio of survivin-2B/survivin was decreased in the late stages of renal cell carcinoma.
Localization (decreased) of survivin associated with renal cancer
4) Confidence 0.36 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 1.19 Pain Relevance 0.06
As described above, we are sure that survivin-targeting immunotherapy with survivin-2B peptide should be a reasonable strategy.
Localization (targeting) of survivin
5) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2430193 Disease Relevance 0.77 Pain Relevance 0
These data indicate that survivin is produced and secreted locally in the joints of RA patients.
Localization (secreted) of survivin in joints associated with rheumatoid arthritis
6) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.70 Pain Relevance 0.15
The number of in vitro leukocyte-activating stimuli (e.g. lipopolysaccharide, PHA, TSST-1, Concanavalin A) will not induce secretion of survivin.
Localization (secretion) of survivin in leukocyte
7) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.98 Pain Relevance 0.13

General Comments

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