INT182321

Context Info Confidence 0.28 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.32 Pain Relevance 0.16

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2) intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)

Anatomy Link Frequency THP-1 2 GLI2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 10 99.16 rheumatoid arthritis 67 90.20 Inflammatory response 3 64.44 methotrexate 17 5.00 Mechanotransduction 8 5.00 cytokine 4 5.00 Arthritis 4 5.00 Leflunomide 2 5.00 cINOD 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 14 99.16 Cancer 50 91.28 Rheumatoid Arthritis 67 90.20 Metastasis 23 83.76 Osteoporosis 2 77.20 Arthropathy 32 54.64 Stress 2 54.40 Bone Cancer 6 54.20 Adhesions 2 51.92 Apoptosis 27 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Gli2 and PTHrP expression did not increase for moduli above 1 GPa.

Neg (not) Positive_regulation (increase) of Gene_expression (expression) of Gli2

1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.94 Pain Relevance 0

To assess the role of survivin in the inflammatory process, the human mononuclear cell line THP-1 was transfected with oligonucleotides targeting different regions of survivin mRNA.

Positive_regulation (transfected) of Gene_expression (transfected) of THP-1 in THP-1 associated with inflammation

2) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.37 Pain Relevance 0.16

General Comments

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