INT182322

Context Info Confidence 0.11 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.37 Pain Relevance 0.98

cell differentiation (GLI2) cell proliferation (GLI2) nucleus (GLI2) intracellular (GLI2) cilium (GLI2) cytoplasm (GLI2)

Anatomy Link Frequency macrophages 7 THP-1 3 monocytes 2 GLI2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 7 97.76 COX-2 inhibitor 52 89.04 Inflammation 38 87.76 rheumatoid arthritis 67 79.64 cINOD 42 65.12 Pain 12 62.04 Arthritis 8 61.84 Inflammatory response 3 53.88 methotrexate 17 5.00 diclofenac 4 5.00

Disease Link Frequency Relevance Heat Atherosclerotic Plaque 12 98.84 Cancer 129 94.96 Colon Cancer 44 88.48 INFLAMMATION 48 87.76 Atherosclerosis 36 84.32 Rheumatoid Arthritis 67 79.64 Death 27 77.68 Apoptosis 98 76.08 Myocardial Infarction 32 67.76 Pain 12 62.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Remarkably, the presence of THP1 macrophages or treatment with IL-1?

Negative_regulation (presence) of Gene_expression (macrophages) of THP1 in macrophages

1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.80 Pain Relevance 0.05

Successful transfection with the inhibitory sequence was confirmed by a downregulation of survivin expression in THP-1 lysates as assessed by ELISA.

Negative_regulation (downregulation) of Gene_expression (expression) of THP-1 in THP-1

2) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065333 Disease Relevance 0.28 Pain Relevance 0.14

COX-2 inhibition decreases 27-hydroxylase and ABCA1 in THP-1 monocytes

Negative_regulation (decreases) of in THP-1 Gene_expression (monocytes) of THP-1 in monocytes

3) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0

PGD2 did not inhibit foam cell formation in SC560-treated THP-1 macrophages.

Negative_regulation (treated) of Gene_expression (macrophages) of THP-1 in macrophages

4) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.13 Pain Relevance 0.03

We showed that in cultured THP-1 human monocytes/macrophages, inhibition of COX-1, COX-2, or both reduced expression of 27-hydroxylase and ABCA1 message (real-time reverse transcription-polymerase chain reaction) and protein (immunoblot).

Negative_regulation (reduced) of Gene_expression (expression) of THP-1 in macrophages

5) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.58 Pain Relevance 0.38

We showed that in cultured THP-1 human monocytes/macrophages, inhibition of COX-1, COX-2, or both reduced expression of 27-hydroxylase and ABCA1 message (real-time reverse transcription-polymerase chain reaction) and protein (immunoblot).

Negative_regulation (reduced) of in monocytes Gene_expression (expression) of THP-1 in macrophages

6) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.58 Pain Relevance 0.38

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