INT182338

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 14.26
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Glrb) endoplasmic reticulum (Glrb) plasma membrane (Glrb)
Anatomy Link Frequency
bowel 3
macrophages 1
immune cells 1
knee joint 1
polymorphonuclear leukocytes 1
Glrb (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 144 99.80 Very High Very High Very High
rheumatoid arthritis 416 99.76 Very High Very High Very High
Arthritis 254 99.16 Very High Very High Very High
Inflammation 260 98.88 Very High Very High Very High
Crohn's disease 24 98.24 Very High Very High Very High
psoriasis 6 94.88 High High
corticosteroid 30 92.16 High High
member 8 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Synovitis 160 100.00 Very High Very High Very High
Recurrence 4 100.00 Very High Very High Very High
Low Back Pain 144 99.80 Very High Very High Very High
Rheumatoid Arthritis 416 99.76 Very High Very High Very High
Disease 766 99.52 Very High Very High Very High
Seronegative Spondarthritis 178 99.16 Very High Very High Very High
Inflammatory Bowel Disease 54 98.88 Very High Very High Very High
INFLAMMATION 182 98.08 Very High Very High Very High
Hyperplasia 90 95.12 Very High Very High Very High
Psoriasis 6 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although certainly not excluding a secondary effector function for lymphocytes in SpA or for macrophages in RA synovitis, these findings point towards distinct pathogenetic mechanisms in the two diseases and fit well with the hypothesis that SpA synovitis is primarly driven by innate immune cells with secondary alterations in lymphocyte activation and functions [28].
Gene_expression (synovitis) of SpA in immune cells associated with synovitis, rheumatoid arthritis and disease
1) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.19 Pain Relevance 0.24
With the exception of anticitrulline and mAb 12A staining, which were found almost exclusively in RA, all investigated histopathological parameters showed a wide range of scores within the SpA group, reflecting wide interindividual variability.
Gene_expression (group) of SpA associated with rheumatoid arthritis
2) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0.95 Pain Relevance 0.54
Again, there were no significant differences between the two clusters with regard to the SpA subtypes (12 AS, 21 USpA, 24 PsA, 3 inflammatory bowel disease, and 2 reactive arthritis in cluster 1 versus 7 AS, 3 USpA, 9 PsA, and 1 inflammatory bowel disease in cluster 2), indicating the absence of a relation between histopathology and disease phenotypes.
Gene_expression (subtypes) of SpA in bowel associated with seronegative spondarthritis, spinal inflammation, inflammation, disease and arthritis
3) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.45 Pain Relevance 0.57
As for the SpA cohort, all RA patients had at least one swollen knee joint and had active disease, with a mean SJC of 9.2 ± 6.6, a mean serum CRP of 58 ± 67 mg/L, and a mean ESR of 41 ± 27 mm/hour.
Gene_expression (cohort) of SpA in knee joint associated with rheumatoid arthritis and disease
4) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0.83 Pain Relevance 0.34
We previously shown that these CD163+ macrophages, but not the overall number of CD68+ macrophages, are increased in SpA synovitis and play a specific role in the disease pathogenesis [2,26].
Gene_expression (synovitis) of SpA in macrophages associated with synovitis and disease
5) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.20 Pain Relevance 0.20
Although there were slightly more AS samples in cluster 2, the different SpA subtypes were found both in cluster 1 (4 AS, 14 USpA, 16 PsA, 4 inflammatory bowel disease, 1 reactive arthritis) and in cluster 2 (15 AS, 10 USpA, 17 PsA, 1 reactive arthritis), confirming that synovial histopathology is not basically different between SpA subtypes.
Gene_expression (subtypes) of SpA in bowel associated with seronegative spondarthritis, spinal inflammation, inflammation and arthritis
6) Confidence 0.51 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.11 Pain Relevance 0.62
Prediction of global disease activity in individual SpA samples
Gene_expression (samples) of SpA associated with disease
7) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.03 Pain Relevance 0.24
Considering the data in RA synovitis, the increase of specific macrophage subsets and polymorphonuclear leukocytes (PMNs) in SpA synovium compared with RA [2], and the strong and rapid reduction of synovial macrophages, T lymphocytes, and PMNs during treatment with anti-tumor-necrosis-factor (TNF)-?
Gene_expression (synovium) of SpA in polymorphonuclear leukocytes associated with necrosis, cancer, synovitis and rheumatoid arthritis
8) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.67 Pain Relevance 0.53
Since we had previously found no major differences between these SpA subgroups for the synovial histopathology markers used in the present study, we considered them collectively as having SpA (unpublished data).
Gene_expression (subgroups) of SpA
9) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.33 Pain Relevance 0.50
In this context, the present finding that local synovial features are correlated with systemic inflammatory parameters such as CRP and ESR strengthens the concept that peripheral synovitis, although not present in all SpA patients, contributes significantly to disease severity.
Neg (not) Gene_expression (present) of SpA associated with inflammation, synovitis and disease
10) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.27 Pain Relevance 0.30
Furthermore, the involvement of genetic factors arising from outside the HLA region is suggested by the large non-HLA component of the relative recurrence risk for the SpA estimated in sib-pairs (?
Gene_expression (component) of SpA associated with recurrence
11) Confidence 0.26 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 0.67 Pain Relevance 0.28
Depending on its clinical features, SpA is classically subdivided into the following subsets: ankylosing spondylitis (AS), which is the prototypical form characterized by predominant axial skeletal involvement and advanced radiographic sacroiliitis, psoriatic arthritis (PsA), arthritis associated with inflammatory bowel disease (AIBD), reactive arthritis (ReA), and undifferentiated SpA (uSpA).
Gene_expression (subdivided) of SpA in bowel associated with seronegative spondarthritis, spinal inflammation, sacroiliitis, inflammation and arthritis
12) Confidence 0.26 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2689651 Disease Relevance 1.58 Pain Relevance 0.74

General Comments

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