INT182344

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.92
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Glrb) endoplasmic reticulum (Glrb) plasma membrane (Glrb)
Anatomy Link Frequency
macrophages 2
polymorphonuclear leukocytes 2
Glrb (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 82 99.68 Very High Very High Very High
Arthritis 48 97.28 Very High Very High Very High
Inflammation 48 94.00 High High
spinal inflammation 26 53.28 Quite High
corticosteroid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Synovitis 32 100.00 Very High Very High Very High
Rheumatoid Arthritis 82 99.68 Very High Very High Very High
Disease 146 98.68 Very High Very High Very High
Seronegative Spondarthritis 34 97.28 Very High Very High Very High
Cancer 4 94.64 High High
INFLAMMATION 34 94.52 High High
Necrosis 4 94.40 High High
Hyperplasia 18 92.52 High High
Arthritis 14 69.88 Quite High
Low Back Pain 26 53.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously shown that these CD163+ macrophages, but not the overall number of CD68+ macrophages, are increased in SpA synovitis and play a specific role in the disease pathogenesis [2,26].
Positive_regulation (increased) of Gene_expression (synovitis) of SpA in macrophages associated with synovitis and disease
1) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.20 Pain Relevance 0.20
Considering the data in RA synovitis, the increase of specific macrophage subsets and polymorphonuclear leukocytes (PMNs) in SpA synovium compared with RA [2], and the strong and rapid reduction of synovial macrophages, T lymphocytes, and PMNs during treatment with anti-tumor-necrosis-factor (TNF)-?
Positive_regulation (increase) of Gene_expression (synovium) of SpA in polymorphonuclear leukocytes associated with necrosis, cancer, synovitis and rheumatoid arthritis
2) Confidence 0.33 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 1.72 Pain Relevance 0.54

General Comments

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