INT182347

Context Info Confidence 0.24 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.98 Pain Relevance 0.28

plasma membrane (Glrb, Cd163) transport (Glrb) extracellular region (Cd163) endoplasmic reticulum (Glrb)

Anatomy Link Frequency macrophages 1 Glrb (Mus musculus) Cd163 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 24 100.00 rheumatoid arthritis 41 65.44 Arthritis 24 15.44 spinal inflammation 13 13.88 corticosteroid 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 17 100.00 Disease 73 99.74 Hyperplasia 9 98.04 Rheumatoid Arthritis 41 65.44 Seronegative Spondarthritis 17 15.44 Low Back Pain 13 13.88 Inflammatory Bowel Disease 4 12.00 Synovitis 16 5.00 Arthritis 7 5.00 Necrosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, it appears that global disease activity in SpA is essentially associated with inflammatory infiltration with macrophages – especially the CD163+ subset – and PMNs as well as with lining-layer hyperplasia.

SpA Binding (associated) of CD163 in macrophages associated with inflammation, disease and hyperplasia

1) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065336 Disease Relevance 0.98 Pain Relevance 0.28

General Comments

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