INT182351

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 38
Total Number 41
Disease Relevance 19.78
Pain Relevance 6.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
brain 4
astrocyte 4
adipocytes 4
macrophages 3
microglia 3
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 305 100.00 Very High Very High Very High
cytokine 103 100.00 Very High Very High Very High
chemokine 16 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
long-term potentiation 26 99.84 Very High Very High Very High
dexamethasone 1013 99.76 Very High Very High Very High
Multiple sclerosis 158 99.66 Very High Very High Very High
Inflammatory response 25 97.24 Very High Very High Very High
glial activation 3 93.72 High High
withdrawal 110 87.76 High High
Disease Link Frequency Relevance Heat
Disease 1486 100.00 Very High Very High Very High
INFLAMMATION 374 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 304 100.00 Very High Very High Very High
Hyperlipidemia 117 100.00 Very High Very High Very High
Infection 87 100.00 Very High Very High Very High
Obesity 268 99.86 Very High Very High Very High
Targeted Disruption 187 99.66 Very High Very High Very High
Demyelinating Disease 150 99.66 Very High Very High Very High
Necrosis 34 99.52 Very High Very High Very High
Cancer 36 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased CC chemokine receptor 3 expression on microglia in apoE-deficient mice after KA administration appeared to facilitate the microglial recruitment and accumulation in the injured areas [90].
Positive_regulation (Increased) of Gene_expression (expression) of apoE in microglia associated with chemokine
1) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.35 Pain Relevance 0.05
Also of note is that apoE levels in the CNS vary during the estrous cycle and estrogen could increase ApoE levels [76, 167–169].
Positive_regulation (vary) of Gene_expression (levels) of apoE
2) Confidence 0.50 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.31 Pain Relevance 0.09
While apoE isoform-specific interactions with A?
Positive_regulation (While) of Gene_expression (isoform) of apoE
3) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 1.18 Pain Relevance 0.06
ApoE receptor ligands also promote other intraneuronal signals via apoE receptors, including PI3 activation, ERK activation, and JNK inhibition [86,96,97] but exactly which receptors promote which signals is unknown.
Positive_regulation (activation) of Gene_expression (receptors) of apoE
4) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.06 Pain Relevance 0.19
The apoE receptor antagonist RAP prevents induction of long-term potentiation (LTP) in hippocampal slices [69].
Positive_regulation (induction) of Neg (prevents) Gene_expression (prevents) of apoE receptor associated with antagonist and long-term potentiation
5) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.15 Pain Relevance 0.34
In humans, decreased expression of apoE caused by some types of genetic disease (Type III hyperlipoproteinaemia associated with familial apolipoprotein E deficiency) leads to an altered lipid profile and an increase in the prevalence of atherosclerosis in these patients [26, 27].
Positive_regulation (leads) of Gene_expression (expression) of apoE associated with atherosclerosis, hyperlipidemia, disease and disorder of lipid metabolism
6) Confidence 0.49 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975993 Disease Relevance 1.02 Pain Relevance 0.04
The ratio of ratio of PC per apoE at apoE concentrations of 0.1,1,10, and 30 ?
Positive_regulation (at) of Gene_expression (concentrations) of apoE
7) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
The ratio of ratio of PC per apoE at apoE concentrations of 0.1,1,10, and 30 ?
Positive_regulation (at) of Gene_expression (per) of apoE
8) Confidence 0.48 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
Primary astrocyte cultures from these same TR APOE mice show LPS-mediated innate immune activation that is greatest with TR APOE2, less with TR APOE3, and least with TR APOE4 that correlates with NF-?
Positive_regulation (activation) of Gene_expression (cultures) of APOE in astrocyte
9) Confidence 0.44 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.35 Pain Relevance 0.08
Primary astrocyte cultures from these same TR APOE mice show LPS-mediated innate immune activation that is greatest with TR APOE2, less with TR APOE3, and least with TR APOE4 that correlates with NF-?
Positive_regulation (same) of Gene_expression (these) of APOE in astrocyte
10) Confidence 0.44 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.35 Pain Relevance 0.08
Most transgenic mouse models focus on overexpressing human APP, PS1, tau, or APOE variants.


Positive_regulation (overexpressing) of Gene_expression (overexpressing) of APOE associated with targeted disruption
11) Confidence 0.36 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 1.35 Pain Relevance 0.03
4 is associated to greater production of pro-inflammatory cytokines than ApoE?
Positive_regulation (associated) of Gene_expression (production) of ApoE associated with inflammation and cytokine
12) Confidence 0.32 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2998033 Disease Relevance 0.61 Pain Relevance 0.27
4 performs this function worse than ApoE?
Positive_regulation (worse) of Gene_expression (than) of ApoE
13) Confidence 0.32 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2998033 Disease Relevance 0.59 Pain Relevance 0.40
Conversion of ApoE?
Positive_regulation (Conversion) of Gene_expression (Conversion) of ApoE
14) Confidence 0.32 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2998033 Disease Relevance 0.68 Pain Relevance 0.22
This may relate partially to the increased ApoE levels observed in APPswe/CCL2 mice produced by microglia and macrophages.
Positive_regulation (increased) of Gene_expression (levels) of ApoE in macrophages
15) Confidence 0.28 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.55 Pain Relevance 0.07
Transient expression of ApoE was induced after 10 days of culture, but these levels were undetectable at later time points.
Positive_regulation (induced) of Gene_expression (expression) of ApoE
16) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.21
Induction of ApoE production
Positive_regulation (Induction) of Gene_expression (production) of ApoE
17) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.43 Pain Relevance 0.07
Of the conditions tested, five induced ApoE expression after 10 days of treatment; these were Dex, NSC-CM, AIM, ost and cig 30 (Figure 2a).
Positive_regulation (induced) of Gene_expression (expression) of ApoE associated with dexamethasone
18) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.19 Pain Relevance 0.13
This suggested that for sustained ApoE expression, induction is required at least weekly.
Positive_regulation (required) of Gene_expression (expression) of ApoE
19) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.28 Pain Relevance 0.26
To confirm that Dex was solely responsible for the induction of ApoE secretion, we tested whether the two additional components of AIM induced ApoE expression.
Spec (whether) Positive_regulation (induced) of Gene_expression (expression) of ApoE associated with dexamethasone
20) Confidence 0.22 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.05 Pain Relevance 0.24

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