INT182357

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 19.55
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Klra8) plasma membrane (Klra8)
Anatomy Link Frequency
E1a 8
granulocyte 1
macrophage 1
Klra8 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 37 94.80 High High
chemokine 8 73.76 Quite High
Inflammatory response 6 68.64 Quite High
rheumatoid arthritis 55 54.92 Quite High
Inflammation 72 15.44 Low Low
Arthritis 34 5.00 Very Low Very Low Very Low
Potency 22 5.00 Very Low Very Low Very Low
methotrexate 13 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
palliative 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 606 100.00 Very High Very High Very High
Infection 326 100.00 Very High Very High Very High
Apoptosis 261 99.66 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 237 99.28 Very High Very High Very High
Necrosis 4 97.40 Very High Very High Very High
Cancer 797 97.04 Very High Very High Very High
Repression 9 94.08 High High
Salivary Gland Disease 12 90.40 High High
Melanoma 125 86.04 High High
INFLAMMATION 76 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CMV-reactive PBLs were stimulated with specific pp65 CMV peptide (amino acid sequence: TPRVTGGGAM, from Proimmune, Oxford, United Kingdom) in the presence of 50 U/mL IL-2 and 10 ng/mL IL-7 for up to 8 days prior to staining with anti-TCR?
Gene_expression (peptide) of CMV associated with cytomegalovirus infection
1) Confidence 0.65 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.20 Pain Relevance 0.14
Virions for the lentiviral vectors HJ57, pHIV-shI-GFP [10], [11], M420 (GFP lentiviral control used for PBMC and mouse experiments) and maC46(M589) were generated by transient transfection of 293T cells in a five plasmid system with the transfer vector and separate plasmids that expresses Gag-Pol (pHDM-Hgpm2), Tat (pHDM-tat1b), Rev (pRC-CMV rev1B) and VSV-G (pHDM VSV-G) or in a three plasmid system with the transfer vector and separate plasmids that express Gag-Pol, Tat and Rev (pCMV-dR8.91 [33]) and VSV-G (pHCMV-VSV-G [34]) in D10 medium supplemented with sodium benzoate.
Gene_expression (expresses) of CMV associated with cytomegalovirus infection
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.35 Pain Relevance 0
Replication-deficient HIV-1 vector particles expressing GFP were produced by transient transfection of 293T cells using plasmids that express GFP (M420), Gag Pol, Tat and Rev (pCMV-dR8.91) and JRFL HIV-1 envelope [35].
Gene_expression (express) of CMV associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.45 Pain Relevance 0
A375 or B16 cells infected with Ad-hTERT-E1a-Apoptin, Ad-CMV-E1a-Apoptin, Ad-hTERT-E1a and Ad-CMV-E1a produced E1a proteins (36 kDa); however, cells infected with Ad-hTERT-Apoptin, Ad-CMV-Apoptin or Ad-mock did not (Figure 1B and 1C).
Gene_expression (produced) of Ad-CMV-E1a-Apoptin in E1a associated with cytomegalovirus infection
4) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.19 Pain Relevance 0
A375 or B16 cells infected with Ad-hTERT-E1a-Apoptin, Ad-CMV-E1a-Apoptin, Ad-hTERT-E1a and Ad-CMV-E1a produced E1a proteins (36 kDa); however, cells infected with Ad-hTERT-Apoptin, Ad-CMV-Apoptin or Ad-mock did not (Figure 1B and 1C).
Gene_expression (produced) of Ad-CMV-E1a in E1a associated with cytomegalovirus infection
5) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.11 Pain Relevance 0
However, in HEM cells, the dose-dependent inhibition was only observed in the Ad-CMV-E1a and Ad-CMV-E1a-Apoptin experimental groups.
Gene_expression (groups) of Ad-CMV-E1a in E1a associated with cytomegalovirus infection
6) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.39 Pain Relevance 0
However, in HEM cells, the dose-dependent inhibition was only observed in the Ad-CMV-E1a and Ad-CMV-E1a-Apoptin experimental groups.
Gene_expression (groups) of Ad-CMV-E1a-Apoptin in E1a associated with cytomegalovirus infection
7) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.33 Pain Relevance 0
In A375 and B16 cells, infection with the adenoviruses expressing Apoptin were observed predominantly in a late apoptotic stage; however, infection with Ad-CMV-E1a or Ad-hTERT-E1a were seen in mainly an early apoptotic stage.
Gene_expression (infection) of Ad-CMV-E1a in E1a associated with cytomegalovirus infection, apoptosis and infection
8) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.37 Pain Relevance 0
However, it is clear from the mean survival results that the mice given Ad-CMV-E1a-Apoptin or Ad-hTERT-E1a-Apoptin showed the longest survival.
Gene_expression (given) of Ad-CMV-E1a-Apoptin in E1a associated with cytomegalovirus infection
9) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.65 Pain Relevance 0
In the HEM cell line, infection with Ad-CMV-Apoptin, Ad-hTERT-E1a-Apoptin and Ad-CMV-E1a-Apoptin, but not Ad-hTERT-Apoptin, Ad-hTERT-E1a, Ad-CMV-E1a or Ad-mock, produced Apoptin protein (Figure 1D).
Gene_expression (produced) of Ad-CMV-E1a in E1a associated with cytomegalovirus infection and infection
10) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.06 Pain Relevance 0
In the HEM cell line, infection with Ad-CMV-Apoptin, Ad-hTERT-E1a-Apoptin and Ad-CMV-E1a-Apoptin, but not Ad-hTERT-Apoptin, Ad-hTERT-E1a, Ad-CMV-E1a or Ad-mock, produced Apoptin protein (Figure 1D).
Gene_expression (produced) of Ad-CMV-E1a-Apoptin in E1a associated with cytomegalovirus infection and infection
11) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.10 Pain Relevance 0
can substitute for allostimulation in inducing expression of the CMV IE-1 gene [29,38], but for complete CMV reactivation it is likely that other checkpoints must be overcome [39], perhaps regulated by other cytokines such as interleukin-13 and granulocyte/macrophage colony-stimulating factor, which are known to promote the replication of human CMV [38].
Gene_expression (expression) of CMV IE-1 gene in macrophage associated with cytomegalovirus infection and cytokine
12) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065340 Disease Relevance 1.44 Pain Relevance 0.17
Using pGL3-Melk as a reporter, the 1×- and 2×-TetO2-H1 promoters were co-transfected with increasing amounts of a CMV-TetROpt expression plasmid in the absence of Dox.
Gene_expression (expression) of CMV-TetROpt associated with cytomegalovirus infection
13) Confidence 0.01 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.47 Pain Relevance 0
can substitute for allostimulation in inducing expression of the CMV IE-1 gene [29,38], but for complete CMV reactivation it is likely that other checkpoints must be overcome [39], perhaps regulated by other cytokines such as interleukin-13 and granulocyte/macrophage colony-stimulating factor, which are known to promote the replication of human CMV [38].
Gene_expression (expression) of CMV IE-1 gene in granulocyte associated with cytomegalovirus infection and cytokine
14) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065340 Disease Relevance 1.44 Pain Relevance 0.17

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