INT182368

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cast) cell cycle (Cast) cytoplasm (Cast)
Anatomy Link Frequency
chondrocyte 1
IgG (Mus musculus)
Cast (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 21 81.60 Quite High
methotrexate 6 63.92 Quite High
Inflammation 25 49.48 Quite Low
chemokine 2 48.16 Quite Low
cytokine 5 47.56 Quite Low
Arthritis 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 100.00 Very High Very High Very High
Viral Infection 10 84.20 Quite High
Rheumatoid Arthritis 21 81.60 Quite High
Autoimmune Disease 19 77.76 Quite High
Enterovirus Infection 3 73.00 Quite High
Targeted Disruption 3 65.04 Quite High
Diabetes Mellitus 1 60.00 Quite High
Bacterial Respiratory Disease 2 54.64 Quite High
Infection 32 51.16 Quite High
INFLAMMATION 26 49.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of interest are responses to the following: collagen type II, proteoglycans and chondrocyte glycoprotein 39; nuclear lamins, topoisomerase II and RA33 antigen (heterogeneous nuclear ribonucleoprotein A2); cytoplasmic antigens such as anti-neutrophil cytoplasmic antibodies; extracellular antigens such as keratin and IgG, the target of typical rheumatoid factors; and apoptosis-related proteins such as annexin V, calpastatin, vimentin and filaggrin [107-115].
IgG Regulation (target) of calpastatin in chondrocyte associated with apoptosis
1) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065340 Disease Relevance 0.99 Pain Relevance 0.11

General Comments

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