INT182374

Context Info Confidence 0.15 First Reported 2005 Last Reported 2006 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 9 Disease Relevance 1.88 Pain Relevance 0

transport (Lman1) vesicle-mediated transport (Lman1) Golgi apparatus (Lman1) endoplasmic reticulum (Lman1)

Anatomy Link Frequency vesicle 2 testis 1 nucleus 1 edge 1 neural 1 Lman1 (Mus musculus)

Pain Link Frequency Relevance Heat isoflurane 5 43.88 nMDA receptor antagonist 5 27.00 nMDA receptor 25 20.52 projection neuron 10 17.28 cytokine 4 8.00 tetrodotoxin 5 5.00 sodium channel 5 5.00 agonist 5 5.00 medulla 5 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 170 99.84 Immunization 56 70.00 Sprains And Strains 20 7.72 Hematological Disease 4 5.00 Body Weight 4 5.00 Adhesions 4 5.00 Hemorrhage 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results indicated that the present rat antisera specifically ­recognized mouse ERGIC-53 or c-Kit.

ERGIC-53 Binding (recognized) of

1) Confidence 0.15 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790970 Disease Relevance 0.16 Pain Relevance 0

Anti-­ERGIC-53 antisera recognized acinar cells in the sublingual gland, and anti-c-Kit antisera recognized spermatogenic and Leydig cells in the testis.

ERGIC-53 Binding (recognized) of in testis

2) Confidence 0.11 Published 2006 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC1790970 Disease Relevance 0.07 Pain Relevance 0

ERGIC-53 with its luminal domain binds glycoprotein ­products in the ER and with its cytosolic domain binds COPII and COPI, the vesicle-coating proteins involved in ER-Golgi antero- and retrograde transports, respectively [4].

ERGIC-53 Binding (binds) of in vesicle

3) Confidence 0.09 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790970 Disease Relevance 0 Pain Relevance 0

ERGIC-53 with its luminal domain binds glycoprotein ­products in the ER and with its cytosolic domain binds COPII and COPI, the vesicle-coating proteins involved in ER-Golgi antero- and retrograde transports, respectively [4].

ERGIC-53 Binding (binds) of in vesicle

4) Confidence 0.09 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1790970 Disease Relevance 0 Pain Relevance 0

Regions immediately surrounding LMAN were also affected, and we cannot rule out an indirect contribution from the partial inactivation of these regions.

LMAN Binding (surrounding) of

5) Confidence 0.05 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1069649 Disease Relevance 0.30 Pain Relevance 0

This observation implies that, in addition to slow neurotrophic effects, LMAN acts on RA rapidly to drive or control song variability, a necessary ingredient of reinforcement learning.

LMAN Binding (acts) of associated with rheumatoid arthritis

6) Confidence 0.05 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1069649 Disease Relevance 0.26 Pain Relevance 0

m anterior to the edge of LMAN, the other in which the injections were approximately 200 ?

LMAN Binding (anterior) of in edge

7) Confidence 0.04 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1069649 Disease Relevance 0.33 Pain Relevance 0

All injection sites were verified by histological examination and were found to be within the target nucleus (see Figure S1), except for TTX injections in LMAN in two birds: one in which the LMAN injection site in one hemisphere was found to be approximately 100 ?

LMAN Neg (except) Binding (birds) of in nucleus

8) Confidence 0.04 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1069649 Disease Relevance 0.33 Pain Relevance 0

Chronic neural recordings in LMAN

LMAN Binding (recordings) of in neural

9) Confidence 0.04 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1069649 Disease Relevance 0.42 Pain Relevance 0

General Comments

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