INT182414

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 2.14
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RAD51) mitochondrion (RAD51) nucleus (RAD51)
cytoplasm (RAD51)
RAD51 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 61.16 Quite High
IPN 22 7.44 Low Low
Chronic pancreatitis 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 8 99.40 Very High Very High Very High
Sprains And Strains 44 98.84 Very High Very High Very High
Pancreatic Cancer 48 95.88 Very High Very High Very High
Cancer 71 94.48 High High
Immunization 22 92.04 High High
Autoimmune Disease 5 80.64 Quite High
Hypersensitivity 25 48.08 Quite Low
Amebiasis 44 42.40 Quite Low
Shock 9 39.20 Quite Low
Contagious Ecthyma 1 35.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recombinant EhRAD51 protein (rEhRAD51) was expressed in E. coli BL21 (DE3) plysS strain as a 6x His-tagged fusion polypeptide and subsequently purified by affinity chromatography (Fig. 5A, lanes 3 and 4).
Gene_expression (expressed) of recombinant EhRAD51 protein associated with sprains and strains
1) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.10 Pain Relevance 0
The EhRAD51 protein is overexpressed in response to DNA damage
Gene_expression (overexpressed) of EhRAD51
2) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.09 Pain Relevance 0
Expression and purification of recombinant EhRAD51 (rEhRAD51) protein
Gene_expression (Expression) of EhRAD51
3) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Our findings showed that EhRAD51 was overexpressed in response to UV-C irradiation, and distributed in both nuclear and cytoplasmic compartments.


Gene_expression (overexpressed) of EhRAD51
4) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
In order to better characterize the EhRAD51 expression and function, we investigated its subcellular location in trophozoites through immunofluorescence and laser confocal microscopy.
Gene_expression (expression) of EhRAD51
5) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Meanwhile, at 30 min after UV-C irradiation, antibodies strongly detected the expected 41 kDa endogenous EhRAD51 in CE, but not in NE (Fig. 5C, higher panel lanes 3 and 4).
Neg (not) Gene_expression (detected) of EhRAD51
6) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.06 Pain Relevance 0
The expression of rEhRAD51 was induced with 1 mM isopropyl beta-D-thiogalacto pyranoside (IPTG) at 37°C for 3 h.
Gene_expression (expression) of rEhRAD51
7) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
To evaluate the expression of the native EhRAD51 in E. histolytica, we performed Western blot assays using anti-EhRAD51 antibodies and protein extracts from irradiated and non-irradiated trophozoites.
Gene_expression (expression) of EhRAD51
8) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.08 Pain Relevance 0
The recombinant EhRAD51 protein (rEhRAD51) was expressed in E. coli BL21 (DE3) plysS strain as a 6x His-tagged fusion polypeptide and subsequently purified by affinity chromatography (Fig. 5A, lanes 3 and 4).
Gene_expression (expressed) of rEhRAD51 associated with sprains and strains
9) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.10 Pain Relevance 0
Expression and purification of recombinant EhRAD51 (rEhRAD51) protein
Gene_expression (Expression) of rEhRAD51
10) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
As in yeast, rad51 paralogs (rad51b, rad51d, xrcc2 and xrcc3) that participate in HR in vertebrates were not found in E. histolytica (Table 1).
Gene_expression (paralogs) of rad51
11) Confidence 0.65 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
The EhRAD51 protein is overexpressed in response to DNA damage
Gene_expression (protein) of EhRAD51
12) Confidence 0.56 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.09 Pain Relevance 0
Production of polyclonal antibodies raised against EhRAD51
Gene_expression (raised) of EhRAD51
13) Confidence 0.56 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.07 Pain Relevance 0
The predicted EhRAD51 conserves the typical architecture of RECA/RAD51 family members
Gene_expression (predicted) of EhRAD51
14) Confidence 0.56 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
At 12 h after genotoxic damage, both cytoplasmic and nuclear EhRAD51 signals were very weak, being EhRAD51 foci-like structures scarce (Fig. 6, panels M-P).
Gene_expression (foci) of EhRAD51
15) Confidence 0.56 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Increasing amounts of rEhRAD51 (0, 2.5, 5 and 7.5 ?
Gene_expression (amounts) of rEhRAD51
16) Confidence 0.56 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
Immunodetection of EhRAD51 in subcellular extracts
Gene_expression (Immunodetection) of EhRAD51
17) Confidence 0.56 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.09 Pain Relevance 0
Cloning of the Ehrad51 gene
Gene_expression (gene) of Ehrad51
18) Confidence 0.56 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0
We also showed that EhRAD51 protein was overexpressed and relocalized in nuclear foci-like structures after DNA damage, and demonstrated that recombinant EhRAD51 function as a recombinase in vitro.
Gene_expression (overexpressed) of EhRAD51
19) Confidence 0.50 Published 2008 Journal BMC Mol Biol Section Body Doc Link PMC2324109 Disease Relevance 0.07 Pain Relevance 0
In response to DNA damage, EhRAD51 protein is overexpressed and relocalized in nuclear foci-like structures.
Gene_expression (overexpressed) of EhRAD51
20) Confidence 0.50 Published 2008 Journal BMC Mol Biol Section Abstract Doc Link PMC2324109 Disease Relevance 0 Pain Relevance 0

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