INT182435

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 1.66
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1)
hydrolase activity, acting on glycosyl bonds (OGG1) nucleolus (OGG1) nucleus (OGG1)
Anatomy Link Frequency
HeLa 3
nucleus 3
kidney cortex 1
crescent 1
terminal segment 1
OGG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 36 94.48 High High
imagery 36 83.76 Quite High
Pain 36 51.76 Quite High
cerebral cortex 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 38 93.96 High High
Cancer 344 92.80 High High
Apoptosis 3 90.08 High High
Tuberous Sclerosis 11 87.76 High High
Sprains And Strains 3 62.48 Quite High
Contagious Ecthyma 36 58.72 Quite High
Cockayne Syndrome 72 54.24 Quite High
Renal Cancer 3 52.16 Quite High
Pain 36 51.76 Quite High
Disease 57 43.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the nucleolar localization of EGFP-hOGG1 is linked to transcription.
Localization (localization) of EGFP-hOGG1
1) Confidence 0.76 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.11 Pain Relevance 0
EGFP/EYFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 localization during S-phase in live cells
Localization (localization) of EGFP-hOGG1
2) Confidence 0.76 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
To compare the localization of EGFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 in living cells during S-phase, stable cell lines were transiently transfected with HcRed-PCNA.
Localization (localization) of EGFP-hOGG1
3) Confidence 0.76 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
EGFP-hOGG1 cells were synchronized at the G1/S boundary, released and allowed to enter S-phase before being treated with 0.04 ?
Localization (released) of EGFP-hOGG1
4) Confidence 0.76 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
EGFP/EYFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 localization during S-phase in live cells
Localization (localization) of EYFP-hOGG1
5) Confidence 0.76 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
As shown in Figure 8B, EGFP-hOGG1-Cys326 is not associated with the nucleoli while the localization of EGFP-hOGG1-Glu326 looks similar to the wild-type protein.


Localization (localization) of EGFP-hOGG1
6) Confidence 0.76 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.03
EGFP/EYFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 localization during S-phase in live cells
Localization (localization) of EYFP-hOGG1
7) Confidence 0.71 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
EGFP/EYFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 localization during S-phase in live cells
Localization (localization) of EGFP-hOGG1
8) Confidence 0.71 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
At this time, EGFP-hOGG1 is mainly distributed evenly throughout the nucleus (Figure 4).
Localization (distributed) of EGFP-hOGG1 in nucleus
9) Confidence 0.71 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
At 2–8 h after nocodazole removal (data not shown), and at the time of double-thymidine block release, the cells are in G1, and EGFP-hOGG1 is mainly homogeneously distributed to the nucleus (Figure 4).
Localization (distributed) of EGFP-hOGG1 in nucleus
10) Confidence 0.71 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
Furthermore, during mitosis, from pro-metaphase to telophase, the EGFP-hOGG1-Glu326 signal was co-localized with the condensed chromosomes (Figure 7B shows examples of cells in pro-metaphase and in telophase).
Localization (localized) of EGFP-hOGG1
11) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
Using this approach we showed that EGFP-hOGG1 was relocalized during the cell cycle and it was associated with the nucleoli during S-phase and with condensed chromosomes during mitosis.
Localization (relocalized) of EGFP-hOGG1
12) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.06 Pain Relevance 0
Transient transfection of HeLa cells with EGFP-hOGG1-Ala326 showed the distribution to be identical to that of EGFP-hOGG1-Cys326 indicating that the presence of the serine residue is important for the correct localization of hOGG1 to the nucleoli (data not shown).


Localization (localization) of hOGG1 in HeLa
13) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
The localization of EGFP-hOGG1 to the nucleoli is linked to transcription
Localization (localization) of EGFP-hOGG1
14) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
EGFP/EYFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 localization during S-phase in live cells
Localization (localization) of EGFP-hOGG1
15) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
To compare the localization of EGFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 in living cells during S-phase, stable cell lines were transiently transfected with HcRed-PCNA.
Localization (localization) of EGFP-hOGG1
16) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
We, therefore, used the EGFP tag to study the subcellular localization of hOGG1.
Localization (localization) of hOGG1
17) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.06 Pain Relevance 0
In addition, to confirm the localization of EGFP-hOGG1 to the nucleoli during S-phase, we visualized sites of replication using anti-BrdU antibodies.
Localization (localization) of EGFP-hOGG1
18) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
Supporting this idea is the restoration of wild-type localization of the EGFP-hOGG1-Glu326 mutant protein that mimicked a phosphorylated serine.
Localization (localization) of EGFP-hOGG1
19) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.09 Pain Relevance 0
Throughout S-phase, EGFP-hOGG1 is localized around the nucleoli as shown in Figure 8A, which shows a cell during S-phase.
Localization (localized) of EGFP-hOGG1
20) Confidence 0.67 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox