INT18244

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2007
Negated 3
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.87
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
frontal cortex 4
neuron 3
PVN 3
pituitary 2
sympathetic nervous system 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 16 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
dexamethasone 7 100.00 Very High Very High Very High
Intracerebroventricular 5 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
Catecholamine 7 99.92 Very High Very High Very High
substance P 29 99.80 Very High Very High Very High
antinociception 2 99.80 Very High Very High Very High
lidocaine 7 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 83 100.00 Very High Very High Very High
Urological Neuroanatomy 7 98.86 Very High Very High Very High
Depression 19 96.36 Very High Very High Very High
Rheumatoid Arthritis 108 93.36 High High
Death 6 91.52 High High
Apoptosis 3 77.60 Quite High
INFLAMMATION 72 75.52 Quite High
Osteoarthritis 1 71.64 Quite High
Convulsion 2 68.04 Quite High
Disease 31 53.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated the effect of general anesthetics on nitrous-oxide-induced CRF activation and antinociception.
Regulation (effect) of Positive_regulation (activation) of CRF associated with antinociception
1) Confidence 0.45 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15496295 Disease Relevance 0 Pain Relevance 0.36
Moreover, TTX inhibited lidocaine-induced iCRH secretion but had no influence on the response of the CRH neuron to procaine.
Neg (no) Regulation (influence) of Positive_regulation (response) of CRH in neuron associated with tetrodotoxin and lidocaine
2) Confidence 0.45 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.13 Pain Relevance 1.16
We evaluated the effects of intracerebroventricular (i.c.v.) administration of beta-endorphin and naloxone, an opioid antagonist, on the induction of c-fos and corticotropin-releasing factor (CRF) mRNA to clarify the effects of beta-endorphin on cellular activity and CRF gene expression in the paraventricular nucleus (PVN) of the rat using in situ hybridization.
Regulation (effects) of in nucleus Positive_regulation (induction) of CRF in PVN associated with antagonist, narcan, opioid and intracerebroventricular
3) Confidence 0.37 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919295 Disease Relevance 0 Pain Relevance 0.35
This study aimed at evaluating the effects of a dynamic physical training programme on circulating levels of corticotropin-releasing hormone (CRH), beta-lipotropin (beta-LPH), and beta-endorphin (beta-EP) after high-intensity training for 6 weeks (60 min twice a week) and after low-intensity training (home-training) for another 6 months in patients with rheumatoid arthritis (RA) and in healthy subjects.
Regulation (effects) of Positive_regulation (levels) of corticotropin-releasing hormone associated with rheumatoid arthritis
4) Confidence 0.31 Published 1994 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 7836027 Disease Relevance 0.33 Pain Relevance 0.24
This study aimed at evaluating the effects of a dynamic physical training programme on circulating levels of corticotropin-releasing hormone (CRH), beta-lipotropin (beta-LPH), and beta-endorphin (beta-EP) after high-intensity training for 6 weeks (60 min twice a week) and after low-intensity training (home-training) for another 6 months in patients with rheumatoid arthritis (RA) and in healthy subjects.
Regulation (effects) of Positive_regulation (levels) of CRH associated with rheumatoid arthritis
5) Confidence 0.31 Published 1994 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 7836027 Disease Relevance 0.33 Pain Relevance 0.24
The increase in immunocyte BE, therefore, seems to depend on the activation of CRH, catecholamines, and serotonin, but to be independent of activation of the hypothalamus-pituitary-adrenal-axis and prostaglandins.
Regulation (depend) of Positive_regulation (activation) of CRH in pituitary associated with catecholamine and serotonin
6) Confidence 0.27 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925095 Disease Relevance 0.12 Pain Relevance 0.42
In the frontal cortex, pretreatment with either SCH23390 or sulpiride did not alter the increases in the CRH mRNA levels induced by repeated 'binge' cocaine.
Neg (not) Regulation (alter) of Neg (not) Positive_regulation (increases) of CRH mRNA in frontal cortex associated with urological neuroanatomy and cocaine
7) Confidence 0.26 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.23 Pain Relevance 0.62
In the frontal cortex, pretreatment with either SCH23390 or sulpiride did not alter the increases in the CRH mRNA levels induced by repeated 'binge' cocaine.
Neg (not) Regulation (alter) of Positive_regulation (induced) of CRH mRNA in frontal cortex associated with urological neuroanatomy and cocaine
8) Confidence 0.26 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.23 Pain Relevance 0.62
The ethanol-treated animals also showed incompetent ability to respond to exogenous beta-EP to alter the lipopolysaccharide-induced CRH mRNA levels.
Regulation (alter) of Positive_regulation (induced) of CRH mRNA
9) Confidence 0.25 Published 2007 Journal Endocrinology Section Abstract Doc Link 17347308 Disease Relevance 0.44 Pain Relevance 0.11
In addition there is evidence of an impaired response of the sympathetic nervous system and enhanced levels of the peripheral proinflammatory neuropeptides CRH and substance P.
Regulation (response) of Positive_regulation (enhanced) of CRH in sympathetic nervous system associated with neuropeptide and substance p
10) Confidence 0.20 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 1.21 Pain Relevance 1.04
We have examined the effects of localised administration of the synthetic glucocorticoid dexamethasone on basal and stress-induced levels of mRNA for both corticotrophin-releasing factor (CRF) and proenkephalin A, in parvocellular neurons of the paraventricular nucleus (PVN).
Spec (examined) Regulation (effects) of in neurons Spec (examined) Positive_regulation (stress-induced) of corticotrophin-releasing factor in PVN associated with stress and dexamethasone
11) Confidence 0.16 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2789345 Disease Relevance 0.38 Pain Relevance 0.09
In CRH deficiency states there is an exaggerated ACTH response due to upregulation of CRH receptors in the anterior pituitary, while in conditions of CRH excess, such as classical depression, the ACTH response is muted.
Regulation (response) of Positive_regulation (upregulation) of CRH in anterior pituitary associated with depression
12) Confidence 0.10 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416451 Disease Relevance 0.46 Pain Relevance 0.14

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