INT182442

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.07
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1)
hydrolase activity, acting on glycosyl bonds (OGG1) nucleolus (OGG1) nucleus (OGG1)
Anatomy Link Frequency
HeLa S3 2
OGG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 5 87.28 High High
Pain 5 74.96 Quite High
Glutamate 5 24.04 Low Low
Disease Link Frequency Relevance Heat
Pain 5 74.96 Quite High
Contagious Ecthyma 5 48.00 Quite Low
Cancer 45 5.00 Very Low Very Low Very Low
Cockayne Syndrome 10 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Aging 5 5.00 Very Low Very Low Very Low
Adenoma 5 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low
Colon Cancer 5 5.00 Very Low Very Low Very Low
Carcinoma 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the distribution of EGFP-hOGG1-Cys326 during mitosis, we created stable cell lines overexpressing EGFP-hOGG1-Cys326.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of EGFP-hOGG1
1) Confidence 0.58 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
Cell-cycle-dependent expression of HOGG1 gene
Positive_regulation (dependent) of Gene_expression (expression) of HOGG1
2) Confidence 0.44 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.07 Pain Relevance 0.07
Overexpression of EGFP and EGFP-hOGG1 in the stable cell lines was examined in nuclear extracts by western blot using anti-OGG1 and anti-GFP specific antibodies.
Positive_regulation (Overexpression) of Spec (examined) Gene_expression (Overexpression) of EGFP-hOGG1
3) Confidence 0.42 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0
We transiently co-transfected HeLa S3 cells with EYFP-hOGG1 and ECFP-PCNA and followed the cells for 20 h.
Positive_regulation (transfected) of Gene_expression (transfected) of EYFP-hOGG1 in HeLa S3
4) Confidence 0.42 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
Northern blot hybridization of synchronized HaCat cells showed a cell-cycle-dependent mRNA expression of hOGG1 with increased transcription of the major nuclear and mitochondrial isoforms during S/G2 (Figure 1).
Positive_regulation (dependent) of Gene_expression (expression) of hOGG1
5) Confidence 0.39 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.03

General Comments

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