INT18245

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Context Info
Confidence 0.17
First Reported 1989
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.28
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
neuron 2
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 21 100.00 Very High Very High Very High
cocaine 16 100.00 Very High Very High Very High
tetrodotoxin 14 99.98 Very High Very High Very High
gABA 5 99.84 Very High Very High Very High
dexamethasone 5 99.04 Very High Very High Very High
Calcium channel 5 97.00 Very High Very High Very High
sodium channel 5 95.36 Very High Very High Very High
carbamazepine 2 94.24 High High
antagonist 3 85.08 High High
local anesthetic 5 80.92 Quite High
Disease Link Frequency Relevance Heat
Convulsion 6 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Isolated or simultaneous pharmacologic blockade of cholinergic (atropine plus hexamethonium), serotonergic (ritanserin), alpha-adrenergic (phentolamine) and/or dopaminergic (compound SCH 23390) receptor subtypes failed to inhibit cocaine-induced iCRH secretion.
Negative_regulation (inhibit) of Localization (secretion) of iCRH associated with cocaine
1) Confidence 0.17 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.81
On the other hand, cocaine-induced iCRH secretion was inhibited by GABA, a potent inhibitor of CRH secretion, dexamethasone, verapamil, a calcium channel blocker, tetrodotoxin, a sodium channel blocker, and carbamazepine, an antiepileptic and antidepressive agent.
Negative_regulation (inhibited) of Localization (secretion) of iCRH associated with tetrodotoxin, gaba, calcium channel, sodium channel, dexamethasone, carbamazepine and cocaine
2) Confidence 0.17 Published 1989 Journal Brain Res. Section Abstract Doc Link 2611679 Disease Relevance 0 Pain Relevance 0.80
In contrast to procaine and lidocaine, TTX inhibited rather than stimulated iCRH secretion.
Negative_regulation (inhibited) of Localization (secretion) of iCRH associated with tetrodotoxin and lidocaine
3) Confidence 0.11 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.14 Pain Relevance 1.10
Moreover, TTX inhibited lidocaine-induced iCRH secretion but had no influence on the response of the CRH neuron to procaine.
Negative_regulation (inhibited) of Localization (secretion) of iCRH in neuron associated with tetrodotoxin and lidocaine
4) Confidence 0.11 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0.14 Pain Relevance 1.14
Verapamil and blockade of serotonergic, alpha-adrenergic and cholinergic receptors did not inhibit the effects of procaine or lidocaine on iCRH secretion, whereas both GABA and dexamethasone exerted inhibitory effects.
Negative_regulation (inhibit) of Localization (secretion) of iCRH associated with gaba, dexamethasone and lidocaine
5) Confidence 0.08 Published 1990 Journal Horm. Metab. Res. Section Abstract Doc Link 1968416 Disease Relevance 0 Pain Relevance 0.96

General Comments

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