INT182452

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.51
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr6) plasma membrane (Cxcr6) signal transducer activity (Cxcr6)
Anatomy Link Frequency
liver 3
spleen 1
T cell 1
Cxcr6 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 75 92.48 High High
cytokine 10 91.52 High High
imagery 50 82.40 Quite High
agonist 5 59.20 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 35 93.60 High High
Death 10 92.88 High High
Hepatitis 85 74.64 Quite High
Adhesions 15 65.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 25.52 Quite Low
Immunodeficiency 5 24.72 Low Low
Infection 15 22.76 Low Low
Cirrhosis 15 5.00 Very Low Very Low Very Low
Autoimmune Hepatitis 10 5.00 Very Low Very Low Very Low
Liver Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we did not observe any significant deficit in hepatic recruitment of CXCR6-deficient cells after short-term transfer of T cell blasts from cxcr6gfp/+ and cxcr6gfp/gfp mice and after in vivo expansion of NKT cells with ?
CXCR6 Binding (recruitment) of in T cell
1) Confidence 0.37 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.13 Pain Relevance 0.11
Because CXCL16 is the only known ligand for CXCR6 and is expressed on liver sinusoids, it is reasonable to hypothesize that CXCR6/CXCL16 interactions result in enhanced survival of CD1d-reactive liver NKT cells.
CXCR6 Binding (interactions) of in liver
2) Confidence 0.37 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.09 Pain Relevance 0.08
We detected CXCL16 binding in GFPhi cells in cxcr6gfp/+, but not cxcr6gfp/gfp mice, in both spleen and liver, confirming that GFPhi cells in heterozygous mice express the receptor and that its expression is bi-allelic (Figure 1A, R1- and R2-gated cells).
cxcr6gfp Binding (binding) of in liver
3) Confidence 0.35 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.06 Pain Relevance 0
The results of this paper lead us to a model in which the number of intravascular patrolling NKT cells, which is regulated by CXCR6–CXCL16 interactions, influences the immune response in liver in two important ways: (1) it determines the frequency of new antigen detection by affecting the visitation rate of parenchymal liver cells, and (2) it governs the total cytokine “power” (pooled secretion capacity) of the hepatic NKT cell population.
CXCR6 Binding (interactions) of in liver associated with cytokine
4) Confidence 0.35 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.17 Pain Relevance 0.14
We detected CXCL16 binding in GFPhi cells in cxcr6gfp/+, but not cxcr6gfp/gfp mice, in both spleen and liver, confirming that GFPhi cells in heterozygous mice express the receptor and that its expression is bi-allelic (Figure 1A, R1- and R2-gated cells).
cxcr6gfp Binding (binding) of in spleen
5) Confidence 0.12 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.06 Pain Relevance 0

General Comments

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