INT182453

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.64
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1)
lysosome (Cd1d1) cytoplasm (Cd1d1)
Anatomy Link Frequency
endothelial cells 2
T cells 2
Cd1d1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 93.52 High High
cytokine 27 85.36 High High
chemokine 68 80.24 Quite High
Arthritis 9 52.08 Quite High
rheumatoid arthritis 80 50.00 Quite Low
antagonist 16 25.20 Quite Low
imagery 40 22.32 Low Low
agonist 20 20.56 Low Low
ketamine 4 14.40 Low Low
fibrosis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bordatella Infection 2 96.08 Very High Very High Very High
INFLAMMATION 54 93.52 High High
Rheumatoid Arthritis 81 89.24 High High
Diabetes Mellitus 4 88.96 High High
Hyperplasia 2 88.56 High High
Arthritis 12 87.92 High High
Hemorrhage 8 87.84 High High
Liver Disease 8 79.36 Quite High
Hepatitis 68 71.96 Quite High
Disease 26 66.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local transforming growth factor beta may play a role in the maintaining DC in an immature state or in the upregulation of CD1a expression [97].
Positive_regulation (upregulation) of Gene_expression (expression) of CD1a
1) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.62 Pain Relevance 0.18
The number of GFPhi CD1d-?
Positive_regulation (number) of Gene_expression (number) of CD1d
2) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.17 Pain Relevance 0
Equal numbers of CD1d-?
Positive_regulation (numbers) of Gene_expression (numbers) of CD1d
3) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.24 Pain Relevance 0
The number of GFPhi CD1d-?
Positive_regulation (number) of Gene_expression (number) of CD1d
4) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.20 Pain Relevance 0
Using flow cytometry, we observed that sinusoid-lining endothelial cells (CD31+ cells and Tie2+ cells) express high levels of CD1d on their surface, and Kupffer cells (F4/80+) and dendritic cells (CD11c-high cells) express lower, but clearly detectable, levels of surface CD1d (Figure 3C).
Positive_regulation (levels) of Gene_expression (express) of CD1d in endothelial cells
5) Confidence 0.30 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.03
Serum lipids promote the expression of CD1d antigen-presenting molecules and enhance the activation of immune responses mediated by CD1d-restricted T cells.
Positive_regulation (promote) of Gene_expression (expression) of CD1d in T cells
6) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.42 Pain Relevance 0

General Comments

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