INT182456

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 1.75
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr6) plasma membrane (Cxcr6) signal transducer activity (Cxcr6)
Anatomy Link Frequency
liver 3
spleen 1
thymus 1
memory T cells 1
intestine 1
Cxcr6 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 240 99.76 Very High Very High Very High
rheumatoid arthritis 104 99.08 Very High Very High Very High
cytokine 33 81.28 Quite High
imagery 140 78.00 Quite High
Inflammation 38 43.68 Quite Low
agonist 14 16.48 Low Low
fibrosis 15 5.00 Very Low Very Low Very Low
ketamine 14 5.00 Very Low Very Low Very Low
anesthesia 14 5.00 Very Low Very Low Very Low
cva 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 123 99.08 Very High Very High Very High
Adhesions 45 95.12 Very High Very High Very High
Hepatitis 238 89.88 High High
Death 28 85.08 High High
Apoptosis 98 72.80 Quite High
Targeted Disruption 28 50.56 Quite High
INFLAMMATION 36 43.68 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 28 34.48 Quite Low
Immunodeficiency 14 33.68 Quite Low
Infection 42 31.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study shows that CXCR6, which is expressed on CD1d-reactive NKT cells, controls the selective accumulation of these cells in the liver.
Gene_expression (expressed) of CXCR6 in liver
1) Confidence 0.77 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.24 Pain Relevance 0.11
Our results indicate that the CXCR6-deficient hepatic NKT cells patrol in the same manner as their CXCR6-expressing counterparts: they both crawl rapidly, lack directional bias, and rapidly stop in response to TCR stimulation.
Gene_expression (counterparts) of CXCR6-expressing
2) Confidence 0.67 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.07 Pain Relevance 0.03
Our results indicate that the CXCR6-deficient hepatic NKT cells patrol in the same manner as their CXCR6-expressing counterparts: they both crawl rapidly, lack directional bias, and rapidly stop in response to TCR stimulation.
Gene_expression (patrol) of CXCR6
3) Confidence 0.67 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.07 Pain Relevance 0.03
To confirm the correlation of GFP expression with that of CXCR6 at the plasma membrane on a per-cell basis, cxcr6gfp/+ lymphocytes were analyzed for binding of CXCL16, the only known ligand of CXCR6, using a CXCL16-Fc fusion protein [19].
Gene_expression (expression) of CXCR6 in lymphocytes
4) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.07 Pain Relevance 0
We next examined the expression of the CXCR6 ligand, the transmembrane chemokine CXCL16, by immunofluorescence confocal microscopy of fixed tissue sections.
Spec (examined) Gene_expression (expression) of CXCR6 associated with chemokine
5) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.05 Pain Relevance 0.05
We also observed that while 50% of thymic and 80% of splenic CD1d-tetramer-positive NKT cells expressed GFP, 99% of such cells expressed GFP/CXCR6 in liver (Figure 1B).
Gene_expression (expressed) of CXCR6 in liver
6) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.03
NK cells expressing CXCR6 represented 20% of NK cells in the liver, but was not observed in other organs, including spleen, thymus, lung, and intestine (Figure 1B; data not shown).


Gene_expression (expressing) of CXCR6 in lung
7) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.04
It is also noteworthy that the defect in CXCR6 expression only affects hepatic NKT cells, and not NKT cells in other locations, suggesting that either the liver is an especially inhospitable environment, or that other survival signals are provided in other NKT-rich organs such as the spleen.
Gene_expression (expression) of CXCR6 in liver
8) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.12 Pain Relevance 0.11
Conventional T cells expressing CXCR6 were also found to be more frequent in liver than in other organs, and a subset of CD3?
Gene_expression (expressing) of CXCR6 in T cells
9) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.03
Because we observed that CXCL16, the chemokine ligand for CXCR6, is expressed on sinusoidal endothelial cells, we initially hypothesized that CXCR6 was critical for the recruitment of blood-borne NKT cells to the hepatic sinusoids, either by initial tethering interactions or by signaling to initiate crawling and patrolling.
Gene_expression (expressed) of CXCR6 in blood associated with chemokine
10) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.24 Pain Relevance 0.17
As CXCR6 is expressed not only on NKT cells, but also on activated and memory T cells, it is possible that this is a general mechanism by which chemokines mediate the survival of effector/memory T cells that patrol at sites of potential toxic damage and antigen entry, thus facilitating rapid and efficient memory T cell responses.
Gene_expression (expressed) of CXCR6 in memory T cells associated with chemokine
11) Confidence 0.60 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.09 Pain Relevance 0.12
CXCR6 was expressed at very low levels on RA and healthy PB monocytes by flow cytometry (MFI <0.46), in agreement with others [30].
Gene_expression (expressed) of CXCR6 in monocytes associated with rheumatoid arthritis
12) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.81 Pain Relevance 0.51
NK cells expressing CXCR6 represented 20% of NK cells in the liver, but was not observed in other organs, including spleen, thymus, lung, and intestine (Figure 1B; data not shown).


Gene_expression (expressing) of CXCR6 in thymus
13) Confidence 0.20 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.04
NK cells expressing CXCR6 represented 20% of NK cells in the liver, but was not observed in other organs, including spleen, thymus, lung, and intestine (Figure 1B; data not shown).


Gene_expression (expressing) of CXCR6 in spleen
14) Confidence 0.20 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.04
NK cells expressing CXCR6 represented 20% of NK cells in the liver, but was not observed in other organs, including spleen, thymus, lung, and intestine (Figure 1B; data not shown).


Gene_expression (expressing) of CXCR6 in intestine
15) Confidence 0.20 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.04

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