INT18246

Context Info Confidence 0.53 First Reported 1990 Last Reported 1990 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0.29

cell-cell signaling (POMC, GNRH1) extracellular space (POMC, GNRH1) signal transduction (POMC, GNRH1) extracellular region (POMC, GNRH1) small molecule metabolic process (POMC) cytoplasm (POMC)

Anatomy Link Frequency pituitary 2 POMC (Homo sapiens) GNRH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 1 99.76 Morphine 2 93.20

Disease Link Frequency Relevance Heat Stress 7 95.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Opioids, primarily beta-endorphin, originating through CRF-independent mechanisms in the brain or even the pituitary may also inhibit GnRH production.

beta-endorphin Spec (may) Negative_regulation (inhibit) of Gene_expression (production) of GnRH in pituitary associated with opioid

1) Confidence 0.53 Published 1990 Journal Int. J. Fertil. Section Abstract Doc Link 1968447 Disease Relevance 0.49 Pain Relevance 0.29

General Comments

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