INT182465

Context Info Confidence 0.28 First Reported 2005 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.72 Pain Relevance 0.29

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1) lysosome (Cd1d1) cytoplasm (Cd1d1)

Anatomy Link Frequency T-cell 2 histiocytes 1 Cd1d1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 3 98.80 chemokine 45 90.32 Inflammation 28 90.00 imagery 30 86.24 fibrosis 7 5.00 cytokine 6 5.00 cva 6 5.00 ketamine 3 5.00 anesthesia 3 5.00 agonist 3 5.00

Disease Link Frequency Relevance Heat Cv General 4 Under Development 3 98.80 Hepatitis 51 96.72 Reprotox - General 1 11 93.20 INFLAMMATION 24 90.00 Disease 2 87.08 Hyperplasia 14 82.96 Lymphatic System Cancer 1 80.72 Pseudolymphoma 1 76.20 Adenoma 3 71.52 Necrosis 3 68.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The reduction in the number of CD1d-reactive T cells in the CXCR6-deficient mice might also be expected to decrease the efficiency of patrolling.

Negative_regulation (reduction) of CD1d in T cells

1) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.42 Pain Relevance 0.05

We have not characterized this population further, but believe that it is a subset of NKT cells with reduced reactivity for CD1d-?

Negative_regulation (reduced) of CD1d

2) Confidence 0.28 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.08

CXCR6-deficient mice exhibited a selective and severe reduction of CD1d-reactive NKT cells in the liver and decreased susceptibility to T-cell-dependent hepatitis.

Negative_regulation (reduction) of CD1d in T-cell associated with hepatitis

3) Confidence 0.28 Published 2005 Journal PLoS Biology Section Abstract Doc Link PMC1073691 Disease Relevance 0.10 Pain Relevance 0.09

The histiocytes stained positive for CD68, S100 by immunohistochemistry and negative for CD1a, while ultrastructural examination confirmed emperipolesis [25].

Negative_regulation (negative) of CD1a in histiocytes

4) Confidence 0.22 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2082069 Disease Relevance 1.21 Pain Relevance 0.07

General Comments

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