INT182468

Context Info Confidence 0.61 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 4.08 Pain Relevance 0.48

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1) lysosome (Cd1d1) cytoplasm (Cd1d1)

Anatomy Link Frequency liver 1 endothelial cells 1 T cells 1 Cd1d1 (Mus musculus)

Pain Link Frequency Relevance Heat chemokine 70 99.06 Central nervous system 22 88.48 Inflammation 42 78.32 cytokine 16 69.28 Inflammatory response 10 58.56 imagery 40 47.72 anesthesia 6 5.00 ketamine 4 5.00 fibrosis 4 5.00 ischemia 4 5.00

Disease Link Frequency Relevance Heat Autoimmune Hepatitis 8 99.62 Infection 118 99.40 Adhesions 12 98.52 Hepatitis 68 98.20 Togavirus Infection 150 97.44 Apoptosis 60 96.72 Death 12 96.32 Immunodeficiency 6 94.00 Syndrome 2 92.64 Viral Meningitis 8 91.92

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MHC class I receptors such as Cd1d1, B2m and Ap3d1 were also upregulated at 96 hr post infection.

Positive_regulation (upregulated) of Cd1d1 associated with infection

1) Confidence 0.61 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.94 Pain Relevance 0.13

Using flow cytometry, we observed that sinusoid-lining endothelial cells (CD31+ cells and Tie2+ cells) express high levels of CD1d on their surface, and Kupffer cells (F4/80+) and dendritic cells (CD11c-high cells) express lower, but clearly detectable, levels of surface CD1d (Figure 3C).

Positive_regulation (levels) of CD1d in endothelial cells

2) Confidence 0.45 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.03

Several molecules associated with MHC-I-mediated presentation such as B2m, Fcerg1 and Cd1d1 were also upregulated in our study.

Positive_regulation (upregulated) of Cd1d1

3) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.61 Pain Relevance 0.22

ConA-induced hepatitis, considered to be an experimental model for human autoimmune hepatitis [11], is strictly dependent on CD1d-reactive NKT cells [9,10].

Positive_regulation (dependent) of CD1d associated with autoimmune hepatitis and hepatitis

4) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.33 Pain Relevance 0

The reduced accumulation of CXCR6-deficient CD1d-reactive NKT cells in the liver is likely to result at least partially from increased cell death due to the lack of a CXCR6-mediated survival signal.

Positive_regulation (accumulation) of CD1d in liver associated with death

5) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.10 Pain Relevance 0.06

We reasoned that because CXCL16 is a trans-membrane chemokine, CXCR6 could be involved in the intravascular movement of the CD1d-reactive T cells by affecting their adhesion or polarization during their migration within sinusoids.

Positive_regulation (movement) of CD1d in T cells associated with chemokine and adhesions

6) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.10 Pain Relevance 0.05

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