INT182468

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.08
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1)
lysosome (Cd1d1) cytoplasm (Cd1d1)
Anatomy Link Frequency
liver 1
endothelial cells 1
T cells 1
Cd1d1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 70 99.06 Very High Very High Very High
Central nervous system 22 88.48 High High
Inflammation 42 78.32 Quite High
cytokine 16 69.28 Quite High
Inflammatory response 10 58.56 Quite High
imagery 40 47.72 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Hepatitis 8 99.62 Very High Very High Very High
Infection 118 99.40 Very High Very High Very High
Adhesions 12 98.52 Very High Very High Very High
Hepatitis 68 98.20 Very High Very High Very High
Togavirus Infection 150 97.44 Very High Very High Very High
Apoptosis 60 96.72 Very High Very High Very High
Death 12 96.32 Very High Very High Very High
Immunodeficiency 6 94.00 High High
Syndrome 2 92.64 High High
Viral Meningitis 8 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MHC class I receptors such as Cd1d1, B2m and Ap3d1 were also upregulated at 96 hr post infection.
Positive_regulation (upregulated) of Cd1d1 associated with infection
1) Confidence 0.61 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.94 Pain Relevance 0.13
Using flow cytometry, we observed that sinusoid-lining endothelial cells (CD31+ cells and Tie2+ cells) express high levels of CD1d on their surface, and Kupffer cells (F4/80+) and dendritic cells (CD11c-high cells) express lower, but clearly detectable, levels of surface CD1d (Figure 3C).
Positive_regulation (levels) of CD1d in endothelial cells
2) Confidence 0.45 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.03
Several molecules associated with MHC-I-mediated presentation such as B2m, Fcerg1 and Cd1d1 were also upregulated in our study.
Positive_regulation (upregulated) of Cd1d1
3) Confidence 0.44 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.61 Pain Relevance 0.22
ConA-induced hepatitis, considered to be an experimental model for human autoimmune hepatitis [11], is strictly dependent on CD1d-reactive NKT cells [9,10].
Positive_regulation (dependent) of CD1d associated with autoimmune hepatitis and hepatitis
4) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.33 Pain Relevance 0
The reduced accumulation of CXCR6-deficient CD1d-reactive NKT cells in the liver is likely to result at least partially from increased cell death due to the lack of a CXCR6-mediated survival signal.
Positive_regulation (accumulation) of CD1d in liver associated with death
5) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.10 Pain Relevance 0.06
We reasoned that because CXCL16 is a trans-membrane chemokine, CXCR6 could be involved in the intravascular movement of the CD1d-reactive T cells by affecting their adhesion or polarization during their migration within sinusoids.
Positive_regulation (movement) of CD1d in T cells associated with chemokine and adhesions
6) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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