INT182468
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
MHC class I receptors such as Cd1d1, B2m and Ap3d1 were also upregulated at 96 hr post infection. | |||||||||||||||
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Using flow cytometry, we observed that sinusoid-lining endothelial cells (CD31+ cells and Tie2+ cells) express high levels of CD1d on their surface, and Kupffer cells (F4/80+) and dendritic cells (CD11c-high cells) express lower, but clearly detectable, levels of surface CD1d (Figure 3C). | |||||||||||||||
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Several molecules associated with MHC-I-mediated presentation such as B2m, Fcerg1 and Cd1d1 were also upregulated in our study. | |||||||||||||||
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ConA-induced hepatitis, considered to be an experimental model for human autoimmune hepatitis [11], is strictly dependent on CD1d-reactive NKT cells [9,10]. | |||||||||||||||
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The reduced accumulation of CXCR6-deficient CD1d-reactive NKT cells in the liver is likely to result at least partially from increased cell death due to the lack of a CXCR6-mediated survival signal. | |||||||||||||||
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We reasoned that because CXCL16 is a trans-membrane chemokine, CXCR6 could be involved in the intravascular movement of the CD1d-reactive T cells by affecting their adhesion or polarization during their migration within sinusoids. | |||||||||||||||
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