INT182474

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 17
Total Number 29
Disease Relevance 14.58
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh5) plasma membrane (Cdh5)
Anatomy Link Frequency
endothelial cells 10
vessels 3
CHO 3
TEK 2
dendritic cells 1
Cdh5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 45 99.40 Very High Very High Very High
imagery 523 98.98 Very High Very High Very High
Spinal cord 41 98.96 Very High Very High Very High
cytokine 96 98.40 Very High Very High Very High
metalloproteinase 10 88.72 High High
cva 20 84.28 Quite High
positron emission tomography 183 66.16 Quite High
Central nervous system 12 57.24 Quite High
ischemia 40 55.12 Quite High
anesthesia 26 36.16 Quite Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 392 100.00 Very High Very High Very High
Systemic Sclerosis 34 100.00 Very High Very High Very High
Cancer 1642 99.68 Very High Very High Very High
Neuroblastoma 64 99.16 Very High Very High Very High
Adhesions 13 96.94 Very High Very High Very High
Apoptosis 42 95.84 Very High Very High Very High
Glioma 25 90.96 High High
Solid Tumor 39 87.92 High High
Nerve Degeneration 6 87.24 High High
Hypersensitivity 6 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The targeting system also favored this profile as the murine VE-cad epitope is expressed in the vessel lumen and, therefore, is readily accessible to the CNT construct.
Gene_expression (expressed) of VE-cad epitope in lumen associated with coronary artery disease
1) Confidence 0.57 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.69 Pain Relevance 0.08
The construct rapidly accesses the tumor vasculature and then can specifically bind to the monomeric VE-cad that is expressed in the neovasculature but cannot bind to resting vasculature with tight cell–cell contacts at the adherens junctions.
Neg (cannot) Gene_expression (expressed) of VE-cad in vasculature associated with coronary artery disease and cancer
2) Confidence 0.49 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.92 Pain Relevance 0.08
LS174T, Chinese hamster ovary (CHO), and CHO cells that stably expressed human VE-cad were assessed for VE-cad expression by flow cytometry.
Gene_expression (expression) of VE-cad in CHO associated with coronary artery disease
3) Confidence 0.49 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.34 Pain Relevance 0.03
In addition, lysates from these cell lines were tested for VE-cad expression by Western blot analysis.
Gene_expression (expression) of VE-cad associated with coronary artery disease
4) Confidence 0.49 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.36 Pain Relevance 0.06
LS174T, Chinese hamster ovary (CHO), and CHO cells that stably expressed human VE-cad were assessed for VE-cad expression by flow cytometry.
Gene_expression (expressed) of VE-cad in CHO associated with coronary artery disease
5) Confidence 0.49 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.34 Pain Relevance 0.03
CD31/CD144 expression increased swiftly to 10–15% after subculture in collagen as confirmed by FACS analysis, as compared to only 1–2% using the conventional EB culturing technique (Figure 1D).
Gene_expression (expression) of CD144
6) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
The E4G10 antibody specifically targeted the monomeric vascular endothelial-cadherin (VE-cad) epitope expressed in the tumor angiogenic vessels.
Gene_expression (expressed) of vascular endothelial-cadherin in vessels associated with coronary artery disease and cancer
7) Confidence 0.44 Published 2010 Journal Int J Nanomedicine Section Abstract Doc Link PMC2962274 Disease Relevance 0.64 Pain Relevance 0.04
Large interendothelial junctions in cancerous tissue may be as large as 500 nm, whereas in healthy tissue, these junctions are ~8 nm.7 Angiogenic endothelial cells express the monomeric vascular endothelial-cadherin (VE-cad) epitope on the cell surface that upon dimerizing with another monomeric copy of VE-cad on an adjoining cell surface leads to the formation of tight adherens junctions between the cells.8–12 The antibody E4G10 binds only to the monomeric VE-cad and not to the homodimeric form (the binding region is masked in the homodimers that form the tight cell–cell contacts), thus conferring the specificity for targeting angiogenic and poorly joined endothelial cells in vivo while not binding to normal endothelium or the LS174T tumor.
Gene_expression (express) of vascular endothelial-cadherin in endothelial cells associated with coronary artery disease and cancer
8) Confidence 0.44 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.94 Pain Relevance 0.05
Whereas Flk-1 expression is not endothelium-restricted [14], this result, together with the reduced vascular endothelial-cadherin (VE-Cad) expression at days 6 and 8 (Figure 5F), suggests that dorsomorphin treatment decreases endothelial cell differentiation.
Gene_expression (expression) of VE-Cad in endothelial cell associated with coronary artery disease
9) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0.10 Pain Relevance 0
Whereas Flk-1 expression is not endothelium-restricted [14], this result, together with the reduced vascular endothelial-cadherin (VE-Cad) expression at days 6 and 8 (Figure 5F), suggests that dorsomorphin treatment decreases endothelial cell differentiation.
Gene_expression (expression) of vascular endothelial-cadherin in endothelial cell associated with coronary artery disease
10) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483414 Disease Relevance 0.10 Pain Relevance 0
In order to define at a molecular level the changes occurring at each stage of hESC differentiation into endothelial cells, we next performed transcriptional profiling using whole human genome microarrays on (i) undifferentiated hESCs, (ii) day-12 EBs, (iii) hESC-ECs after CD31/CD144 sort, and (iv) HUVECs as positive control (n?
Gene_expression (sort) of CD144 in endothelial cells
11) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
When CD31+/CD144+ cells were cultured in endothelial growth medium, the majority of cells were adherent and expressed endothelial markers (CD31, CD144) at the endothelial cell adherent junctions as well as von Willebrand factor (vWF) located within the cytoplasm (Figure 2B).
Gene_expression (expressed) of CD144 in endothelial cell
12) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
The E4G10 antibody specifically targeted the monomeric vascular endothelial-cadherin (VE-cad) epitope expressed in the tumor angiogenic vessels.
Gene_expression (expressed) of VE-cad in vessels associated with coronary artery disease and cancer
13) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Abstract Doc Link PMC2962274 Disease Relevance 0.64 Pain Relevance 0.04
The NIR FMT imaging data in vivo yielded an estimate of the number of VE-cad expressed per vascular endothelial cell.
Gene_expression (expressed) of VE-cad in endothelial cell associated with coronary artery disease and imagery
14) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 1.15 Pain Relevance 0.13
Large interendothelial junctions in cancerous tissue may be as large as 500 nm, whereas in healthy tissue, these junctions are ~8 nm.7 Angiogenic endothelial cells express the monomeric vascular endothelial-cadherin (VE-cad) epitope on the cell surface that upon dimerizing with another monomeric copy of VE-cad on an adjoining cell surface leads to the formation of tight adherens junctions between the cells.8–12 The antibody E4G10 binds only to the monomeric VE-cad and not to the homodimeric form (the binding region is masked in the homodimers that form the tight cell–cell contacts), thus conferring the specificity for targeting angiogenic and poorly joined endothelial cells in vivo while not binding to normal endothelium or the LS174T tumor.
Gene_expression (express) of VE-cad in endothelial cells associated with coronary artery disease and cancer
15) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.94 Pain Relevance 0.05
The VE-cad epitope was not expressed by the LS174T tumor and is a murine protein in the vessels of a mouse model.
Neg (not) Gene_expression (expressed) of VE-cad epitope in vessels associated with coronary artery disease and cancer
16) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 1.14 Pain Relevance 0.08
LS174T, Chinese hamster ovary (CHO), and CHO cells that stably expressed human VE-cad were assessed for VE-cad expression by flow cytometry.
Gene_expression (expression) of VE-cad in CHO associated with coronary artery disease
17) Confidence 0.38 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.34 Pain Relevance 0.03
As expected, CD31 and CD144 were upregulated during the two-step differentiation and expressed robustly after sorting (Figure 2A).
Gene_expression (expressed) of CD144
18) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
Gated Flk1+ cells showed CD11b negative, CD45 negative, CD31 negative, VE-cadherin negative, E-cadherin negative, CD34 negative or CD90 negative (Figure 2).
Neg (negative) Gene_expression (negative) of VE-cadherin
19) Confidence 0.32 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2955572 Disease Relevance 0.06 Pain Relevance 0.03
It has been shown that microvascular endothelial cells, isolated from murine spinal cord, morphologically similar to BBB endothelial cells, express reduced amounts of several prominent BBB proteins such as tight junction-associated proteins ZO-1 and occluding, adherens junction-associated proteins beta-catenin and VE-cadherin, and the efflux transporter P-glycoprotein [50].
Gene_expression (express) of VE-cadherin in endothelial cells associated with spinal cord
20) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.27 Pain Relevance 0.12

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