INT182476

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.65
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh5) plasma membrane (Cdh5)
Anatomy Link Frequency
endothelial cells 4
lymphocytes 2
Cdh5 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 18 85.24 High High
chemokine 16 79.52 Quite High
positron emission tomography 23 59.76 Quite High
imagery 69 50.00 Quite Low
ischemia 16 34.08 Quite Low
fibrosis 6 33.60 Quite Low
anesthesia 4 24.00 Low Low
isoflurane 11 23.28 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 40 100.00 Very High Very High Very High
Adhesions 4 89.24 High High
Thromboembolism 1 86.08 High High
Cv General 3 Under Development 14 85.24 High High
Cv Unclassified Under Development 31 80.48 Quite High
Cancer 176 78.00 Quite High
Thrombosis Related Under Development 2 70.40 Quite High
Hepatitis 17 68.76 Quite High
Coronary Heart Disease 8 66.40 Quite High
Autoimmune Hepatitis 2 63.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD31/CD144 expression increased swiftly to 10–15% after subculture in collagen as confirmed by FACS analysis, as compared to only 1–2% using the conventional EB culturing technique (Figure 1D).
Positive_regulation (increased) of Gene_expression (expression) of CD144
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
In addition, lysates from these cell lines were tested for VE-cad expression by Western blot analysis.
Positive_regulation (tested) of Gene_expression (expression) of VE-cad associated with coronary artery disease
2) Confidence 0.32 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962274 Disease Relevance 0.37 Pain Relevance 0.06
In order to define at a molecular level the changes occurring at each stage of hESC differentiation into endothelial cells, we next performed transcriptional profiling using whole human genome microarrays on (i) undifferentiated hESCs, (ii) day-12 EBs, (iii) hESC-ECs after CD31/CD144 sort, and (iv) HUVECs as positive control (n?
Positive_regulation (after) of Gene_expression (sort) of CD144 in endothelial cells
3) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
The accumulation of lymphocytes in liver sinusoids (devoid of E/P-selectins, PECAM, CD34, and VE-cadherin, and low in VCAM-1) appears to result from mechanisms distinct from those involved in multistep extravasation of intravascular lymphocytes [14].
Positive_regulation (accumulation) of Gene_expression (devoid) of VE-cadherin in lymphocytes
4) Confidence 0.10 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.34 Pain Relevance 0.04
For example, doxycycline targets the adherens junction in vascular endothelial cells by inducing total vascular endothelial-cadherin expression while decreasing vascular endothelial-cadherin phosphorylation (41).
Positive_regulation (inducing) of Gene_expression (expression) of endothelial-cadherin in endothelial cells
5) Confidence 0.04 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 0.94 Pain Relevance 0.08

General Comments

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