INT182479

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.43
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr6) extracellular space (Cxcl16) plasma membrane (Cxcr6)
signal transducer activity (Cxcr6)
Anatomy Link Frequency
liver 3
Cxcl16 (Mus musculus)
Cxcr6 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 60 100.00 Very High Very High Very High
cytokine 8 91.52 High High
agonist 4 59.20 Quite High
imagery 40 39.92 Quite Low
Inflammation 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 8 97.52 Very High Very High Very High
Apoptosis 28 93.60 High High
Hepatitis 68 74.64 Quite High
Adhesions 12 23.00 Low Low
Cirrhosis 12 5.00 Very Low Very Low Very Low
Infection 12 5.00 Very Low Very Low Very Low
Autoimmune Hepatitis 8 5.00 Very Low Very Low Very Low
Liver Disease 8 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because CXCL16 is the only known ligand for CXCR6 and is expressed on liver sinusoids, it is reasonable to hypothesize that CXCR6/CXCL16 interactions result in enhanced survival of CD1d-reactive liver NKT cells.
CXCL16 Binding (ligand) of CXCR6 in liver
1) Confidence 0.33 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.10 Pain Relevance 0.08
The LocusLink (http://www.ncbi.nlm.nih.gov/LocusLink) accession number for the CXCR6/Bonzo/STRL33 chemokine receptor is 80901and for its CXCL16 ligand is 66102.



CXCL16 Binding (ligand) of CXCR6 associated with chemokine
2) Confidence 0.33 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0 Pain Relevance 0.05
The results of this paper lead us to a model in which the number of intravascular patrolling NKT cells, which is regulated by CXCR6–CXCL16 interactions, influences the immune response in liver in two important ways: (1) it determines the frequency of new antigen detection by affecting the visitation rate of parenchymal liver cells, and (2) it governs the total cytokine “power” (pooled secretion capacity) of the hepatic NKT cell population.
CXCL16 Binding (interactions) of CXCR6 in liver associated with cytokine
3) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.17 Pain Relevance 0.14
The results of this paper lead us to a model in which the number of intravascular patrolling NKT cells, which is regulated by CXCR6–CXCL16 interactions, influences the immune response in liver in two important ways: (1) it determines the frequency of new antigen detection by affecting the visitation rate of parenchymal liver cells, and (2) it governs the total cytokine “power” (pooled secretion capacity) of the hepatic NKT cell population.
CXCL16 Binding (interactions) of CXCR6 in liver associated with cytokine
4) Confidence 0.32 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.17 Pain Relevance 0.14

General Comments

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