INT182487

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.32
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Agtr1a) aging (Agtr1a) Golgi apparatus (Agtr1a)
plasma membrane (Agtr1a) cytoplasm (Agtr1a) signal transducer activity (Agtr1a)
Anatomy Link Frequency
smooth muscle cells 2
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 81.60 Quite High
Inflammation 66 50.00 Quite Low
ischemia 16 50.00 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 14 99.44 Very High Very High Very High
Hypertension 4 98.32 Very High Very High Very High
Apoptosis 3 95.12 Very High Very High Very High
Disease 28 84.12 Quite High
Middle Cerebral Artery Infarction 27 81.48 Quite High
INFLAMMATION 71 81.24 Quite High
Stress 10 67.28 Quite High
Cancer 91 50.00 Quite Low
Brain Hemorrhage 5 50.00 Quite Low
Pressure And Volume Under Development 5 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed for the first time a significant increase in the expression of endothelin ETB, angiotensin AT1, and 5-hydroxytryptamine 5-HT1B receptors in smooth muscle cells not only in the ischemic MCA but also in smooth muscle cells of cerebral microvessels associated with the ischemic region (Fig. 6 and 7).
Positive_regulation (increase) of Gene_expression (expression) of AT1 in smooth muscle cells
1) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2553085 Disease Relevance 0.29 Pain Relevance 0
Hypoxia has been shown to strongly induce the expression of AT1b but not AT1a.
Positive_regulation (induce) of Gene_expression (expression) of AT1a associated with hypoxia
2) Confidence 0.10 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

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