INT182505

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 13.18
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
pancreas 3
immune system 2
carotid body 1
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 661 99.54 Very High Very High Very High
cytokine 80 97.64 Very High Very High Very High
bradykinin 2 97.48 Very High Very High Very High
chemokine 54 97.08 Very High Very High Very High
Inflammatory response 20 93.76 High High
Dopamine 6 92.32 High High
cINOD 30 91.88 High High
antagonist 50 90.76 High High
Arthritis 10 72.84 Quite High
fibrosis 40 65.12 Quite High
Disease Link Frequency Relevance Heat
Injury 90 99.68 Very High Very High Very High
INFLAMMATION 711 99.54 Very High Very High Very High
Hypoxia 140 99.48 Very High Very High Very High
Cancer 910 99.38 Very High Very High Very High
Disease 281 99.32 Very High Very High Very High
Solid Tumor 40 98.96 Very High Very High Very High
Colon Cancer 10 98.84 Very High Very High Very High
Stress 104 98.62 Very High Very High Very High
Hypertension 40 98.32 Very High Very High Very High
Apoptosis 23 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypoxia has been shown to strongly induce the expression of AT1b but not AT1a.
Positive_regulation (induce) of Gene_expression (expression) of AT1b associated with hypoxia
1) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.03 Pain Relevance 0.04
Most, if not all, solid tumours utilise inflammation processes, which, through the over-expression and activation of AT1 and the subsequent expression of a number of inflammatory cytokines and chemokines, allow for tumour protection from the immune system through immunosuppression, as well as tumour progression and metastasis.
Positive_regulation (over) of Gene_expression (expression) of AT1 in immune system associated with chemokine, inflammation, cancer, solid tumor, metastasis and cytokine
2) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.37 Pain Relevance 0.48
Is it evolution that causes over expression of AT1?
Positive_regulation (causes) of Gene_expression (expression) of AT1
3) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.50 Pain Relevance 0.03
Hypoxia has been demonstrated to induce the expression of both AT1b (AT1a and AT1b are subsets of AT1) and AT2 receptors in the rat carotid body and pancreas [39,40].
Positive_regulation (induce) of Gene_expression (expression) of AT1b in pancreas associated with hypoxia
4) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.12 Pain Relevance 0.05
Stresses and cell damage on the growing tumour boundary could potentially be causing the expression of AT1.
Positive_regulation (causing) of Gene_expression (expression) of AT1 associated with stress and cancer
5) Confidence 0.65 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.81 Pain Relevance 0.04
Significant evidence has been shown that AT1 receptors are upregulated during disease and that AT2 receptor expression follows behind AT1 expression during injury and healing.
Positive_regulation (follows) of Gene_expression (expression) of AT1 associated with injury and disease
6) Confidence 0.47 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.91 Pain Relevance 0.39
Is it evolution that causes over expression of AT1?
Positive_regulation (over) of Gene_expression (expression) of AT1
7) Confidence 0.47 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.50 Pain Relevance 0.03
Of particular interest is that activation of LOX-1 by ox-LDL induces the expression of the AT1 receptor [36].
Positive_regulation (induces) of Gene_expression (expression) of AT1 receptor
8) Confidence 0.47 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.25 Pain Relevance 0.07
As rVSMCs express very low levels (20 fmol/mg) of AT1aR, which is insufficient for coimmunoprecipitation, we transfected these cells with HA-AT1aR to probe a direct interaction between AT1aR and TRPV4.
Positive_regulation (transfected) of Gene_expression (express) of AT1aR
9) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Two mechanisms for upregulation of AT1 are discussed: 1) evolutionary changes to take advantage of this pro-inflammatory control mechanism, 2) AT1 expression induced by an alternating environment of hypoxia and oxidative stress.
Positive_regulation (induced) of Gene_expression (expression) of AT1 associated with stress, inflammation and hypoxia
10) Confidence 0.44 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.57 Pain Relevance 0.50
2AR homodimer showed no difference, but significant changes in fluorescence levels were observed upon co-expression with the AT1R homodimer or with ?
Positive_regulation (observed) of Gene_expression (expression) of AT1R
11) Confidence 0.34 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
AT1R undergoes homo- and heterodimerize with many other receptors, including bradykinin B2, ?
Positive_regulation (undergoes) of Gene_expression (undergoes) of AT1R associated with bradykinin
12) Confidence 0.30 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0.09
Hypoxia has been demonstrated to induce the expression of both AT1b (AT1a and AT1b are subsets of AT1) and AT2 receptors in the rat carotid body and pancreas [39,40].
Positive_regulation (induce) of in carotid body Gene_expression (expression) of AT1b in pancreas associated with hypoxia
13) Confidence 0.22 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.12 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox