INT182512

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.88
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
immune system 2
heart 2
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 230 99.38 Very High Very High Very High
cytokine 29 97.64 Very High Very High Very High
chemokine 15 97.08 Very High Very High Very High
adenocard 1 95.44 Very High Very High Very High
cINOD 9 91.88 High High
fibrosis 14 91.00 High High
antagonist 21 90.76 High High
Inflammatory mediators 11 79.40 Quite High
Inflammatory response 6 68.96 Quite High
medulla 3 64.96 Quite High
Disease Link Frequency Relevance Heat
Cancer 275 99.44 Very High Very High Very High
INFLAMMATION 248 99.38 Very High Very High Very High
Solid Tumor 12 98.96 Very High Very High Very High
Hypoxia 42 96.44 Very High Very High Very High
Metastasis 22 92.12 High High
Apoptosis 7 91.84 High High
Necrosis 4 91.84 High High
Fibrosis 11 91.00 High High
Heart Rate Under Development 12 90.80 High High
Increased Venous Pressure Under Development 5 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AT1 activation has also been shown to increase the activity of HIF-1?
Positive_regulation (increase) of Positive_regulation (activation) of AT1
1) Confidence 0.47 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.32 Pain Relevance 0.06
Activation of AT1 also causes the expression of TGF-?
Positive_regulation (causes) of Positive_regulation (Activation) of AT1
2) Confidence 0.47 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.87 Pain Relevance 0.20
Most, if not all, solid tumours utilise inflammation processes, which, through the over-expression and activation of AT1 and the subsequent expression of a number of inflammatory cytokines and chemokines, allow for tumour protection from the immune system through immunosuppression, as well as tumour progression and metastasis.
Positive_regulation (over) of Positive_regulation (activation) of AT1 in immune system associated with chemokine, inflammation, cancer, solid tumor, metastasis and cytokine
3) Confidence 0.44 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.37 Pain Relevance 0.48
In patients taking ACE-inhibitors, the blunted production of angiotensin II and the consequent reduced stimulation of AT1- and AT2 receptor may induce an ‘escape phenomenon’, which consists in the accumulation of angiotensin I and production of angiotensin II through alternative synthetic bio-pathways (cathepsine C, chimases).10 This phenomenon, well described in patients with congestive heart failure, may be prognostically important.
Spec (may) Positive_regulation (induce) of Positive_regulation (stimulation) of AT1 in heart associated with heart rate under development
4) Confidence 0.38 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.97 Pain Relevance 0.13
The effects of Ang-II are predominantly mediated via activation of the AT1-receptor which is coupled through guanine nucleotide binding proteins (G-proteins), adenylate cyclase and cyclic adenosine monophosphate (cAMP) as second messenger, as well as phospholipases A2, C and D and their products, arachidonic acid (AA), inositol triphosphate (IP3), or diacylglycerol (DG).
Positive_regulation (mediated) of Positive_regulation (activation) of AT1 associated with adenocard
5) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.35 Pain Relevance 0.10

General Comments

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