INT182513

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.14
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.31
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR2) signal transducer activity (AGTR2)
AGTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 148 98.12 Very High Very High Very High
fibrosis 8 97.64 Very High Very High Very High
bradykinin 1 90.68 High High
ischemia 19 84.96 Quite High
antagonist 14 75.60 Quite High
headache 3 59.24 Quite High
Bioavailability 2 49.84 Quite Low
Onset of action 2 49.60 Quite Low
cytokine 18 45.68 Quite Low
Calcium channel 5 37.56 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 7 98.88 Very High Very High Very High
INFLAMMATION 163 98.12 Very High Very High Very High
Fibrosis 6 97.64 Very High Very High Very High
Injury 20 97.44 Very High Very High Very High
Disease 58 96.88 Very High Very High Very High
Cancer 184 91.52 High High
Cardiovascular Disorder Under Development 2 91.52 High High
Solid Tumor 8 90.60 High High
Natriuresis 2 89.12 High High
Cv General 4 Under Development 10 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The evidence suggests that regulation of the mutually antagonistic angiotensin II receptors (AT1 and AT2) is an essential process in the management of inflammation and wound recovery, and that it is an imbalance in the expression of these receptors that leads to disease.
Regulation (regulation) of AT2 associated with inflammation, injury and disease
1) Confidence 0.14 Published 2004 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1074345 Disease Relevance 2.43 Pain Relevance 0.32
and lipopolysaccharides, through induction of NO and cGMP, all serve to down-regulate AT2 with no effect on AT1 leading to a quicker progression of fibrosis.
Neg (no) Regulation (regulate) of AT2 associated with fibrosis
2) Confidence 0.12 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.95 Pain Relevance 0.31
It has a 24-hour effect on BP control due to blockade of the AT1 receptor, but there may be an increase in angiotensin II concentration acting on AT2 receptors, with consequent vasodilatation.
Regulation (acting) of AT2 associated with increased venous pressure under development
3) Confidence 0.11 Published 2010 Journal Core evidence Section Body Doc Link PMC2899780 Disease Relevance 0.42 Pain Relevance 0.10
Negative effects might arise, since a protective role of the angiotensin type 2 receptor is under discussion [11], [12].
Regulation (role) of angiotensin type 2 receptor
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 0.50 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox