INT182514

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 13.35
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
Anatomy Link Frequency
heart 3
plasma 1
ductus arteriosus 1
endothelium 1
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 86 99.28 Very High Very High Very High
bradykinin 18 98.48 Very High Very High Very High
antagonist 22 98.32 Very High Very High Very High
Inflammatory response 17 96.60 Very High Very High Very High
Dopamine 31 94.32 High High
palliative 12 92.20 High High
fibrosis 15 90.40 High High
TRP channel 35 90.32 High High
Inflammation 178 87.20 High High
headache 4 76.48 Quite High
Disease Link Frequency Relevance Heat
Injury 513 100.00 Very High Very High Very High
Patent Ductus Arteriosus 4 99.76 Very High Very High Very High
Myocardial Infarction 35 98.60 Very High Very High Very High
Cv General 4 Under Development 15 97.28 Very High Very High Very High
Obesity 39 97.04 Very High Very High Very High
Chronic Renal Failure 53 96.88 Very High Very High Very High
Diabetic Retinopathy 144 96.76 Very High Very High Very High
Increased Venous Pressure Under Development 104 96.74 Very High Very High Very High
Renal Disease 145 96.32 Very High Very High Very High
INFLAMMATION 211 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So what purpose does this constitutive interaction of AT1aR and TRPV4, or any other 7TMR with an ion channel, serve?
AT1aR Binding (interaction) of
1) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 1, F and G, we detected a constitutive interaction between the AT1aR and TRPV4, and this interaction is not modulated by angiotensin stimulation during the time course examined in this experiment.
AT1aR Binding (interaction) of
2) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
Although there exist some examples of heterodimer formation between ion channels and 7TMRs (44–47), our data not only provide the first evidence of direct cross-talk between AT1aR and TRPV4 but also report the first example of formation of a multiprotein complex involving ?
AT1aR Binding (talk) of
3) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0.05
AT1aR and TRPV4 form a constitutive complex in the plasma membrane, and angiotensin stimulation leads to recruitment of ?
AT1aR Binding (complex) of in plasma
4) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
What are the functional outcomes of this physical interaction among TRPV4, AT1aR, and ?
AT1aR Binding (interaction) of
5) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2943294 Disease Relevance 0 Pain Relevance 0
In this work [65], the AT1 and AT2 receptors are recognized as having a substantial role in the tissue repair and healing processes of injured arteries.
AT1 Binding (recognized) of
6) Confidence 0.34 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 1.24 Pain Relevance 0.20
Wallukat et al. have detected an autoantibody in the serum of preeclamptic patients that binds to the AT1 receptor and has agonist activity[54].
AT1 Binding (binds) of associated with agonist
7) Confidence 0.28 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.47 Pain Relevance 0.05
Here, we used AT1R with mutations at sites N4, 176, 188 D and ?
AT1R Binding (used) of
8) Confidence 0.25 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0.03
2AR homodimer, ERp57 which interacts only with AT1R-containing dimers, and HSP70 which interacts weakly with both homodimers, but not the heterodimer.
AT1R-containing Binding (dimers) of
9) Confidence 0.25 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0.06 Pain Relevance 0.06
AT1R undergoes homo- and heterodimerize with many other receptors, including bradykinin B2, ?
AT1R Binding (heterodimerize) of associated with bradykinin
10) Confidence 0.21 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0.10
which is essential for AT1 receptor binding.
AT1 Binding (binding) of
11) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.33 Pain Relevance 0.17
Furthermore, AT1 and AT2, AII, and its
AT1 Binding (its) of
12) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.17 Pain Relevance 0.09
AT1-R, leaving AII to interact with the relatively beneficial AT2-R.
AT1 Binding (interact) of
13) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.08 Pain Relevance 0.08
Losartan, which selectively binds to the AT1 receptor, is currently used for reducing central pressures in patients with heart failure [18] and is effective in reducing systemic hypertension.
AT1 receptor Binding (binds) of in heart associated with cv general 4 under development and hypertension
14) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1198258 Disease Relevance 1.59 Pain Relevance 0.05
When angiotensin II binds the angiotensin II type 1 receptor on endothelial cells, it stimulates the production of ROS via NADPH oxidase, increases expression of ICAM-1 and increases ET-1 release from the endothelium [52–54].
angiotensin II type 1 receptor Binding (binds) of in endothelium
15) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.09 Pain Relevance 0.03
Although ACE inhibitors are able to reduce angiotensin II formation, non-ACE dependent pathways have also been identified.137 On the other hand, ARBs antagonize the binding of angiotensin II to the AT1 receptor, which mediates most of the undesirable effects associated with angiotensin II.
AT1 receptor Binding (binding) of
16) Confidence 0.02 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 0.65 Pain Relevance 0.09
In other studies, the incidence of ACE I/D allele genotypes or the variants of the angiotensin I receptor gene did not differ in neonates with AKI compared to neonates without AKI, but they may be associated with patent ductus arteriosus and heart failure and indirectly contribute to CKD [14, 15].
angiotensin I receptor gene Binding (associated) of in heart associated with chronic renal failure, patent ductus arteriosus, injury and myocardial infarction
17) Confidence 0.02 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.41 Pain Relevance 0.13
Valsartan is a specific blocker of the binding of angiotensin II to the AT1 receptor, blocking the vasoconstrictor effect and the adrenal aldosterone secretion induced by this peptide.
AT1 receptor Binding (binding) of
18) Confidence 0.02 Published 2010 Journal Core evidence Section Body Doc Link PMC2899780 Disease Relevance 0.48 Pain Relevance 0.18
Pharmacologic blockade of the RAAS has proven to be an effective therapeutic strategy in the treatment of several cardiovascular disorders, including hypertension, heart failure, renal disease, and atherosclerosis.4 Until now, in clinical practice, the drug classes that provided RAAS inhibition included ACE inhibitors (ACEIs), which block the conversion of Ang I to Ang II, angiotensin receptor blockers (ARBs), which interfere with Ang II binding to its Type 1 receptors, and aldosterone antagonists, which inhibit aldosterone action via the mineralocorticoid receptor (MR) receptor.
angiotensin receptor Binding (binding) of in heart associated with antagonist, renal disease, hypertension, increased venous pressure under development and myocardial infarction
19) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.38 Pain Relevance 0.05
In other studies, the incidence of ACE I/D allele genotypes or the variants of the angiotensin I receptor gene did not differ in neonates with AKI compared to neonates without AKI, but they may be associated with patent ductus arteriosus and heart failure and indirectly contribute to CKD [14, 15].
angiotensin I receptor gene Binding (associated) of in ductus arteriosus associated with chronic renal failure, patent ductus arteriosus, injury and myocardial infarction
20) Confidence 0.01 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.41 Pain Relevance 0.13

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