INT182516

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.84
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
tubule 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 1 99.40 Very High Very High Very High
antagonist 36 99.38 Very High Very High Very High
aspirin 5 98.88 Very High Very High Very High
bradykinin 24 98.00 Very High Very High Very High
cINOD 7 97.92 Very High Very High Very High
withdrawal 2 94.56 High High
corticosteroid 7 93.40 High High
beta blocker 16 85.20 High High
adenocard 15 83.96 Quite High
Bioavailability 1 72.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 97 99.84 Very High Very High Very High
INFLAMMATION 89 99.40 Very High Very High Very High
Proteinuria 18 99.10 Very High Very High Very High
Ocular Hypertension 24 98.68 Very High Very High Very High
Volume Depletion And Dehydration 3 98.64 Very High Very High Very High
Necrosis 4 98.28 Very High Very High Very High
Diabetes Mellitus 155 97.38 Very High Very High Very High
Rhinitis 125 97.28 Very High Very High Very High
Hypertension 171 97.04 Very High Very High Very High
Disorder Of Lipid Metabolism 23 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombolytic therapy where appropriate, beta blocking therapy, ACE inhibition and statin therapy were also recorded.
Negative_regulation (blocking) of Negative_regulation (inhibition) of ACE
1) Confidence 0.42 Published 2008 Journal Ulster Med J Section Body Doc Link PMC2516438 Disease Relevance 0.47 Pain Relevance 0.12
-adrenoceptor antagonist/diuretic is less effective in reducing DBP compared to ACEI/CCBs (but similar SBP reduction) and had less effect on pulse wave velocity [58].
Negative_regulation (reducing) of Negative_regulation (reduction) of ACEI associated with antagonist
2) Confidence 0.41 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2901246 Disease Relevance 0.85 Pain Relevance 0.14
Sixthly, in hypertensive type 2 diabetics, the combination of an ACE inhibitor and a CCB may synergistically reduce proteinuria and the rate of decline in GFR.114 Finally, ACE inhibitors and CCBs stimulate nitric oxide (NO) production through kinin-dependent mechanisms and significantly decrease levels of all inflammatory markers (tumor necrosis factor-?
Negative_regulation (decrease) of Negative_regulation (inhibitors) of ACE associated with necrosis, cancer, diabetes mellitus, inflammatory marker, proteinuria and hypertension
3) Confidence 0.40 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686259 Disease Relevance 1.14 Pain Relevance 0.14
ACE inhibitors are also inhibitors of kininase II and thus prevent the breakdown of bradykinin.
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of ACE associated with bradykinin
4) Confidence 0.31 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 1.78 Pain Relevance 0.10
Compared to baseline, at 3 months there were no significant changes in the proportion of patients taking either angiotensin converting enzyme inhibitors (12/24 versus 8/24: ?
Negative_regulation (taking) of Negative_regulation (inhibitors) of angiotensin converting enzyme
5) Confidence 0.29 Published 2008 Journal Atherosclerosis Section Body Doc Link PMC2292239 Disease Relevance 0.32 Pain Relevance 0.04
By 12 months, the number of patients taking ACE inhibitors had increased significantly compared to baseline (17/24 versus 8/24: ?
Negative_regulation (taking) of Negative_regulation (inhibitors) of ACE
6) Confidence 0.29 Published 2008 Journal Atherosclerosis Section Body Doc Link PMC2292239 Disease Relevance 0.31 Pain Relevance 0.04
Inhibitors of the RAAS (Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers), although they are cardiorenal protective, can lead to temporary worsening of renal function.
Negative_regulation (Inhibitors) of Negative_regulation (inhibitors) of Angiotensin-converting enzyme
7) Confidence 0.28 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3010630 Disease Relevance 0.70 Pain Relevance 0.13
Perindopril, another ACE inhibitor has also been shown to be a potent inhibitor of tumour development and angiogenesis through suppression of the VEGF and the endothelial cell tubule formation [60].
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of ACE in tubule associated with cancer
8) Confidence 0.10 Published 2004 Journal J Inflamm (Lond) Section Body Doc Link PMC1074345 Disease Relevance 0.73 Pain Relevance 0
Examples include ACE inhibitors, ?
Negative_regulation (include) of Negative_regulation (inhibitors) of ACE
9) Confidence 0.02 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2835646 Disease Relevance 0.54 Pain Relevance 0.29

General Comments

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