INT182533

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 5.99
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prtn3) peptidase activity (Prtn3) plasma membrane (Prtn3)
enzyme binding (Prtn3)
Anatomy Link Frequency
plasma 2
epithelial cells 2
lung 2
heart 1
molar 1
Prtn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 24 100.00 Very High Very High Very High
bradykinin 3 100.00 Very High Very High Very High
metalloproteinase 156 99.56 Very High Very High Very High
Inflammation 254 99.20 Very High Very High Very High
qutenza 50 81.64 Quite High
fibrosis 36 76.40 Quite High
cytokine 29 52.68 Quite High
Inflammatory mediators 43 39.00 Quite Low
dorsal root ganglion 27 11.36 Low Low
Thermal hyperalgesia 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 156 100.00 Very High Very High Very High
Hypertension 20 100.00 Very High Very High Very High
Cv General 3 Under Development 4 100.00 Very High Very High Very High
Pulmonary Disease 352 99.46 Very High Very High Very High
Diabetes Mellitus 28 99.40 Very High Very High Very High
INFLAMMATION 235 99.20 Very High Very High Very High
Apoptosis 60 97.92 Very High Very High Very High
Nicotine Addiction 16 97.24 Very High Very High Very High
Pulmonary Emphysema 20 88.44 High High
Pneumonia 76 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Active PR3 is rapidly inactivated in the plasma by SERPIN A1 and alpha2-macroglobulin [10], the PR3-SERPIN A1 complex can therefore only be formed with an active protease and may therefore be a good measure of the amount of active enzyme that has been secreted.
Positive_regulation (inactivated) of PR3 in plasma
1) Confidence 0.37 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.40 Pain Relevance 0.03
Active PR3 is rapidly inactivated in the plasma by SERPIN A1 and alpha2-macroglobulin [10], the PR3-SERPIN A1 complex can therefore only be formed with an active protease and may therefore be a good measure of the amount of active enzyme that has been secreted.
Positive_regulation (inactivated) of PR3 in plasma
2) Confidence 0.37 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.35 Pain Relevance 0.03
PR3–SERPIN A1 levels were similar in males and females, and in those with or without previous histories of hypertension, angina, AMI or heart failure, but were slightly elevated in those with diabetes [547.0 (76.9–4035.5) ng/ml] compared with non-diabetic patients [495.1 (29.3–3118.2) ng/ml; P<0.018].
Positive_regulation (elevated) of PR3 in heart associated with angina, diabetes mellitus, hypertension and myocardial infarction
3) Confidence 0.35 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.80 Pain Relevance 0.10
Standards were produced by incubating PR3 with a 20-fold molar excess of SERPIN A1 (both from Sigma–Aldrich).
Positive_regulation (incubating) of PR3 in molar
4) Confidence 0.33 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.17 Pain Relevance 0
Since then, additional studies have confirmed increased levels of NE in lung samples from COPD patients and demonstrated elevated levels of CG, PR3, uPA, and MMPs -1, -2, -8, -9, and -14 in various lung samples from smokers and COPD patients when compared with healthy subjects (Damiano et al 1986; Reilly and Chapman Jr 1988; Abboud et al 1998; Betsuyaku et al 1996; Finlay et al 1997; Betsuyaku et al 1999; Hill et al 1999; Betsuyaku et al 2000b; Cataldo et al 2000; Imai et al 2001; Beeh et al 2003; Kang et al 2003).
Positive_regulation (elevated) of PR3 in lung associated with nicotine addiction, pulmonary disease and metalloproteinase
5) Confidence 0.31 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.17 Pain Relevance 0.18
Inflammatory cells release various proteinases that exceed the proteinase inhibitor defense of the lung.
Positive_regulation (exceed) of proteinase in lung associated with inflammation
6) Confidence 0.29 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.59 Pain Relevance 0.13
However, increased elastase activity due to acidic proteinase(s) is detected in BAL samples after transfection of alveolar epithelial cells with caspase-3 (Aoshiba et al 2003).
Positive_regulation (increased) of proteinase in epithelial cells
7) Confidence 0.27 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.29 Pain Relevance 0.25
However, increased elastase activity due to acidic proteinase(s) is detected in BAL samples after transfection of alveolar epithelial cells with caspase-3 (Aoshiba et al 2003).
Positive_regulation (due) of proteinase in epithelial cells
8) Confidence 0.27 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.22 Pain Relevance 0.22
We have reported that Gq/11-coupled metabotropic receptor activation such as ATP (P2Y), bradykinin (B2) and proteinase-activated receptor 2 (PAR2) receptors causes potentiation or sensitization of TRPV1 through the PKC-dependent phosphorylation of TRPV1 [16-18,25].
Positive_regulation (activation) of proteinase associated with bradykinin
9) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.13

General Comments

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