INT182535

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.92
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgir) plasma membrane (Ptgir) signal transducer activity (Ptgir)
Anatomy Link Frequency
urinary bladder 1
Ptgir (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 64 100.00 Very High Very High Very High
Hyperalgesia 6 99.76 Very High Very High Very High
Pain 16 98.68 Very High Very High Very High
substance P 24 98.46 Very High Very High Very High
Inflammatory mediators 8 97.32 Very High Very High Very High
IPN 8 95.16 Very High Very High Very High
Thermal hyperalgesia 30 88.24 High High
Inflammatory response 6 85.64 High High
qutenza 100 85.20 High High
withdrawal 10 17.60 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 79 100.00 Very High Very High Very High
Hyperalgesia 36 99.76 Very High Very High Very High
Pain 19 98.68 Very High Very High Very High
Inflammatory Pain 8 95.16 Very High Very High Very High
Bladder Cancer 1 83.84 Quite High
Cystitis 15 78.32 Quite High
Nociception 22 75.44 Quite High
Diabetes Mellitus 1 74.08 Quite High
Sprains And Strains 7 70.08 Quite High
Ganglion Cysts 54 15.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of their receptors (EP and IP, respectively) in inflammation has been well documented, although the EP receptor subtypes involved in this process and the underlying cellular mechanisms remain to be elucidated.
Regulation (role) of IP associated with inflammation
1) Confidence 0.16 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1074353 Disease Relevance 0.54 Pain Relevance 0.45
Given the fact that one of the final targets of both PGE2 and PGI2 is TRPV1 as shown in our study, compounds acting on EP1, IP or TRPV1, or interfering with their interaction could prove useful in the treatment of pain and inflammation.


Regulation (acting) of IP associated with pain and inflammation
2) Confidence 0.11 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.83 Pain Relevance 0.56
Indeed, in the urinary bladder, activation of NK1R by SP induces NF-kappaB translocation, as seen by EMSA results (Figure 9), and up-regulation of pro-inflammatory genes, such as the encoding prostaglandin I2 receptor (Figure 6).
Regulation (regulation) of prostaglandin I2 receptor in urinary bladder associated with inflammation and substance p
3) Confidence 0.08 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.54 Pain Relevance 0.28

General Comments

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