INT182536

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.82
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 50 90.16 High High
antagonist 154 83.28 Quite High
dorsal root ganglion 27 56.52 Quite High
Inflammation 43 35.88 Quite Low
bradykinin 3 10.80 Low Low
Thermal hyperalgesia 15 5.00 Very Low Very Low Very Low
withdrawal 11 5.00 Very Low Very Low Very Low
cINOD 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 81 97.52 Very High Very High Very High
Malignant Neoplastic Disease 44 94.92 High High
Adenocarcinoma 30 72.56 Quite High
Adenoma 1 69.00 Quite High
Endometriosis (extended) 27 68.12 Quite High
Ganglion Cysts 27 56.52 Quite High
Nociception 11 50.00 Quite Low
INFLAMMATION 51 35.88 Quite Low
Ovarian Cancer 42 5.00 Very Low Very Low Very Low
Hyperalgesia 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When temperature ramps were applied to HEK293 cells expressing both TRPV1 and EP1 in the absence of PGE2, heat-evoked currents developed at 40.7 ± 0.3°C (n = 8) (Figure 2D).
Positive_regulation (absence) of Gene_expression (expressing) of EP1
1) Confidence 0.36 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.06 Pain Relevance 0.39
The expressions of COX-1, mPGES-1 and EP1 were all significantly elevated in both the H/M+M and P+U group compared to the more differentiated tumours in the BL+M group.
Positive_regulation (elevated) of Gene_expression (expressions) of EP1 associated with cancer
2) Confidence 0.20 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 2.05 Pain Relevance 0
As FPS cells also express basal levels of EP2 and EP4 receptor (but not detectable EP1 or EP3 receptor), we found that PGE2 and to a much lesser extent PGF2?
Positive_regulation (levels) of Gene_expression (receptor) of EP1
3) Confidence 0.06 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.24 Pain Relevance 0.19
As FPS cells also express basal levels of EP2 and EP4 receptor (but not detectable EP1 or EP3 receptor), we found that PGE2 and to a much lesser extent PGF2?
Positive_regulation (levels) of Neg (not) Gene_expression (detectable) of EP1
4) Confidence 0.06 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.24 Pain Relevance 0.19
As FPS cells also express basal levels of EP2 and EP4 receptor (but not detectable EP1 or EP3 receptor), we found that PGE2 and to a much lesser extent PGF2?
Positive_regulation (levels) of Gene_expression (express) of EP1
5) Confidence 0.06 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.24 Pain Relevance 0.19

General Comments

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