INT182544

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 100 99.28 Very High Very High Very High
bradykinin 6 89.76 High High
dorsal root ganglion 54 89.52 High High
Inflammation 36 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 30 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
withdrawal 10 5.00 Very Low Very Low Very Low
IPN 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 54 89.52 High High
Nociception 22 50.00 Quite Low
INFLAMMATION 46 5.00 Very Low Very Low Very Low
Hyperalgesia 36 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
Inflammatory Pain 8 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we examined whether a similar signal transduction pathway is involved in the regulation of TRPV1 responses through EP1.
Spec (whether) Regulation (regulation) of Gene_expression (responses) of EP1
1) Confidence 0.32 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.11
M, 1.5 min) caused a robust increase in the magnitude of low dose (20 nM) capsaicin-activated currents in HEK293 cells co-expressing TRPV1 with EP1 (0.90 ± 0.04 fold increase, n = 9 for control (Cont.); 4.60 ± 1.03 fold, n = 17 for PGE2, p < 0.05) (Figures 2A and 2B).
Regulation (control) of Gene_expression (co-expressing) of EP1 associated with qutenza
2) Confidence 0.19 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.09 Pain Relevance 0.63

General Comments

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