INT182550

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.73
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger1, Trpv1) cytosol (Trpv1) transport (Trpv1)
signal transduction (Ptger1) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
PGE2 1
Ptger1 (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 6 94.80 High High
qutenza 100 94.16 High High
Pain 14 92.72 High High
Hyperalgesia 6 91.96 High High
Inflammation 36 89.12 High High
agonist 4 86.88 High High
antagonist 6 83.28 Quite High
dorsal root ganglion 54 80.40 Quite High
IPN 8 75.60 Quite High
Thermal hyperalgesia 30 51.28 Quite High
Disease Link Frequency Relevance Heat
Nociception 22 98.92 Very High Very High Very High
INFLAMMATION 46 94.80 High High
Pain 16 92.72 High High
Hyperalgesia 36 91.96 High High
Ganglion Cysts 54 80.40 Quite High
Inflammatory Pain 8 75.60 Quite High
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensitization of TRPV1 by EP1 receptors in mouse
EP1 Negative_regulation (Sensitization) of TRPV1
1) Confidence 0.35 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.08 Pain Relevance 0.61
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

Prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) are major inflammatory mediators that play important roles in pain sensation and hyperalgesia.

EP1 Negative_regulation (Sensitization) of TRPV1 in PGE2 associated with nociception, pain, hyperalgesia and inflammatory mediators
2) Confidence 0.35 Published 2005 Journal Mol Pain Section Title Doc Link PMC1074353 Disease Relevance 0.64 Pain Relevance 0.51

General Comments

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