INT182564

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.77
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2, Trpv1) cytosol (Trpv1) transport (Trpv1)
signal transduction (Ptger2) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 1
afferent neurons 1
Ptger2 (Mus musculus)
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 81 99.60 Very High Very High Very High
Thermal hyperalgesia 45 98.88 Very High Very High Very High
qutenza 150 97.88 Very High Very High Very High
Hyperalgesia 9 93.92 High High
withdrawal 15 89.20 High High
bradykinin 9 75.04 Quite High
Inflammatory mediators 9 74.08 Quite High
Pain 21 67.12 Quite High
c fibre 3 61.96 Quite High
unmyelinated 3 61.60 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 81 99.60 Very High Very High Very High
Hyperalgesia 54 98.88 Very High Very High Very High
INFLAMMATION 69 73.68 Quite High
Nociception 33 69.44 Quite High
Pain 24 67.12 Quite High
Injury 6 16.24 Low Low
Inflammatory Pain 12 5.00 Very Low Very Low Very Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional interaction between TRPV1 and PGE2
PGE2 Binding (interaction) of TRPV1
1) Confidence 0.18 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.60 Pain Relevance 0.90
We next examined the interaction between PGE2 and TRPV1 in mouse DRG neurons using the patch-clamp technique.
PGE2 Spec (examined) Binding (interaction) of TRPV1 in neurons associated with dorsal root ganglion
2) Confidence 0.18 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.59 Pain Relevance 0.91
On the other hand, the PGE2-induced thermal hyperalgesia was almost completely abolished in TRPV1-/- mice, suggesting a functional interaction between PGE2 and TRPV1 (Figure 1A), consistent with a previous report that capsaicin-ablation of primary afferent neurons prevents PGE2-induced thermal hyperalgesia [23].
PGE2 Binding (interaction) of TRPV1 in afferent neurons associated with qutenza and thermal hyperalgesia
3) Confidence 0.18 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.58 Pain Relevance 0.86

General Comments

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