INT182607

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MLH1, MSH3) nuclear chromosome (MSH3) ATPase activity (MLH1)
enzyme binding (MSH3) cell cycle (MLH1)
MLH1 (Homo sapiens)
MSH3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 73.48 Quite High
Inflammation 12 72.68 Quite High
Pain 1 36.88 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 4 86.96 High High
Genomic Instability 2 84.04 Quite High
Cancer 11 77.60 Quite High
INFLAMMATION 11 72.68 Quite High
Bladder Cancer 2 64.40 Quite High
Oral Lichen Planus 35 63.24 Quite High
Skin Cancer 8 58.72 Quite High
Malignant Neoplastic Disease 7 48.80 Quite Low
Pain 1 36.88 Quite Low
Lichen 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mismatch is detected by two complexes, the hMSH2-GTBP/hMSH6 and the hMSH2-hMSH3 heterodimers after interaction with hMLH1-hPMS2 heterodimers, an endonuclease is activated and incises the newly synthesized DNA strand that contains the mutation 14.
hMLH1-hPMS2 Binding (interaction) of hMSH3
1) Confidence 0.04 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.81 Pain Relevance 0.11

General Comments

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