INT182621

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Context Info
Confidence 0.64
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.31
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (MLH1) nucleus (MLH1) cell cycle (MLH1)
Anatomy Link Frequency
germline 4
proximal 1
MLH1 1
MLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 82.24 Quite High
Inflammation 13 81.44 Quite High
Pain 1 45.64 Quite Low
colic 1 30.68 Quite Low
backache 1 18.40 Low Low
COX2 8 5.00 Very Low Very Low Very Low
abdominal pain 8 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 327 99.98 Very High Very High Very High
Colon Cancer 26 99.88 Very High Very High Very High
Nicotine Addiction 3 99.42 Very High Very High Very High
Cancer 307 98.96 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 63 98.48 Very High Very High Very High
Genomic Instability 4 92.80 High High
Carcinoma 83 87.68 High High
Bone Disease 3 85.40 High High
Cleidocranial Dysplasia 11 83.68 Quite High
Polyps 199 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other features of HNPCC involve proximal location of CRC, mucinous or poorly differentiated histology, and better prognosis.
Localization (location) of HNPCC in proximal associated with colorectal cancer
1) Confidence 0.64 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837058 Disease Relevance 0.98 Pain Relevance 0
MMR genes, including hMSH2, hMLH1, hMSH3, hMPS1, hPMS2 and GTBP/hMSH6 are very important in distinguishing and repairing misparing and slippage errors in DNA synthesis.
Localization (important) of hMLH1
2) Confidence 0.21 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.77 Pain Relevance 0.12
In sporadic MSI cases of colon cancer this mutation is found in proximal colon tumors with MLH1 methylation (80% of cases), while in tumors from hereditary nonpolyposis colorectal cancer (HNPCC) cases with MLH1, MSH2 or MSH6 germline mutations, no BRAF mutations are detected.
Localization (methylation) of MLH1 in MLH1 associated with cancer, colon cancer and hereditary nonpolyposis colorectal neoplasms
3) Confidence 0.17 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.60 Pain Relevance 0
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
Localization (located) of hMLH1 in germline
4) Confidence 0.17 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.25 Pain Relevance 0
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
Localization (located) of hMLH1 in germline
5) Confidence 0.17 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.24 Pain Relevance 0
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
Localization (located) of HNPCC in germline
6) Confidence 0.15 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.27 Pain Relevance 0
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
Localization (located) of HNPCC in germline
7) Confidence 0.15 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.27 Pain Relevance 0
Recent data from HNPCC mutation carriers support the assertion that smoking significantly increases CRC risk in HNPCC mutation carriers (hazard ratio of 1.43, P < 0.04) (68).
Localization (risk) of HNPCC associated with colorectal cancer and nicotine addiction
8) Confidence 0.04 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.83 Pain Relevance 0
In order to evaluate this variable a convenience sample of 181 was supplied by COCA secretariat.
Localization (secretariat) of COCA
9) Confidence 0.03 Published 2005 Journal Chiropr Osteopat Section Body Doc Link PMC1151651 Disease Relevance 0.09 Pain Relevance 0

General Comments

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