INT182623

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 5.49
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (MSH2) ATPase activity (MSH2) nucleus (MSH2)
enzyme binding (MSH2) DNA binding (MSH2)
Anatomy Link Frequency
germline 2
epithelium 1
MSH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 82.52 Quite High
Inflammation 48 81.72 Quite High
Pain 4 45.92 Quite Low
COX2 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Oral Lichen Planus 140 99.52 Very High Very High Very High
Hyperplasia 38 99.30 Very High Very High Very High
Skin Cancer 32 99.14 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 22 95.16 Very High Very High Very High
Colorectal Cancer 100 93.28 High High
Genomic Instability 8 93.08 High High
Bladder Cancer 8 91.00 High High
Carcinoma 40 86.20 High High
Cancer 106 84.68 Quite High
INFLAMMATION 44 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunolocalization of hMSH2 was quantitatively analyzed.
Spec (analyzed) Localization (immunolocalization) of hMSH2
1) Confidence 0.77 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.08 Pain Relevance 0
As DNA damage is more prone to occur during the cell cycle, it can be assumed that a higher index of cellular proliferation in OLP would require an increased immunolocalization of hMSH2.
Localization (immunolocalization) of hMSH2 associated with oral lichen planus and hyperplasia
2) Confidence 0.77 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 1.23 Pain Relevance 0
As hMSH2 alterations have been reported in oral squamous cell carcinoma and there are evidences suggesting the association between oral lichen planus and squamous cell carcinoma, in this study, we aim to investigate the immunolocalization of hMSH2 protein in oral lichen planus compared to oral normal mucosa epithelium.

2.

Spec (investigate) Localization (immunolocalization) of hMSH2 in epithelium associated with oral lichen planus and skin cancer
3) Confidence 0.72 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.91 Pain Relevance 0
MMR genes, including hMSH2, hMLH1, hMSH3, hMPS1, hPMS2 and GTBP/hMSH6 are very important in distinguishing and repairing misparing and slippage errors in DNA synthesis.
Localization (important) of hMSH2
4) Confidence 0.72 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074709 Disease Relevance 0.78 Pain Relevance 0.12
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
Localization (located) of hMSH2 in germline
5) Confidence 0.12 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.25 Pain Relevance 0
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
Localization (located) of hMSH2 in germline
6) Confidence 0.12 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.25 Pain Relevance 0

General Comments

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